light chains


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light chains

The small polypeptide chains of antibodies.
See also: chain

light chains

The short polypeptide chains that form the outer parts of the upper arms of the Y-shaped ANTIBODY molecule. The light chains of all antibodies have one length (domain) that is the same for all (the constant domain) and one terminal domain that varies in its amino acid sequence (the variable domain). A domain is a single loop of about 110 amino acids. See also HEAVY CHAINS.
References in periodicals archive ?
2015;7 (s1) (7th International Symposium on Clinical Applications of Free Light Chains and Heavy/light Chain analysis.
Systemic AL amyloidosis (formerly primary amyloidosis) is a monoclonal plasma cell proliferative disorder in which monoclonal immunoglobulin light chains are deposited in tissues.
The group at Mayo Clinic employed antibodies to k and A light chains to capture and concentrate the patient's immunoglobulin.
The IMMUNOFIX[R] kit (The Binding Site, Birmingham, UK) was used to detect and identify the immunoglobulins and their light chains in solubilized cryoglobulins and to evaluate the presence of monoclonal immunoglobulins in this material.
It has been proposed that when the concentration of serum FLCs exceeds 500 mg/L and proteinuria is mainly composed of immunoglobulin light chains, it is extremely likely that the onset of AKI is due to myeloma kidney; in those cases, renal biopsy is usually unnecessary.
Serum free light chains in the diagnosis and monitoring of patients with plasma cell dyscrasias.
Serum reference intervals and diagnostic ranges for free kappa and lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains.
Our case revealed monotypic light-chain restriction with positive kappa light chains and slightly positive lambda light chains, indicating extramedullary plasmacytoma rather than reactive plasma cell infiltration.
Actually, the neck may be strengthened by binding with light chains.
This peptide, made by Fmoc Chemistry (Ansynth, Roosendaal, the Netherlands), inhibits free light chain activity but "does not interfere with IgE-or IgG-mediated mast cell activation.
The light chains of primary amyloidosis are predominantly lambda, in contrast to the kappa light chains seen in LCDD.
Immunoglobulins, produced by plasma cells and B lymphocytes, are built of two identical heavy and light chains and these light chains comprise one of two subtypes, known as kappa ([kappa]) and lambda ([lambda]).