2015;7 (s1) (7th International Symposium on Clinical Applications of Free Light Chains
and Heavy/light Chain
Systemic AL amyloidosis (formerly primary amyloidosis) is a monoclonal plasma cell proliferative disorder in which monoclonal immunoglobulin light chains
are deposited in tissues.
The group at Mayo Clinic employed antibodies to k and A light chains
to capture and concentrate the patient's immunoglobulin.
The IMMUNOFIX[R] kit (The Binding Site, Birmingham, UK) was used to detect and identify the immunoglobulins and their light chains
in solubilized cryoglobulins and to evaluate the presence of monoclonal immunoglobulins in this material.
It has been proposed that when the concentration of serum FLCs exceeds 500 mg/L and proteinuria is mainly composed of immunoglobulin light chains
, it is extremely likely that the onset of AKI is due to myeloma kidney; in those cases, renal biopsy is usually unnecessary.
Serum free light chains
in the diagnosis and monitoring of patients with plasma cell dyscrasias.
Serum reference intervals and diagnostic ranges for free kappa and lambda immunoglobulin light chains
: relative sensitivity for detection of monoclonal light chains
Our case revealed monotypic light-chain restriction with positive kappa light chains
and slightly positive lambda light chains
, indicating extramedullary plasmacytoma rather than reactive plasma cell infiltration.
Actually, the neck may be strengthened by binding with light chains
This peptide, made by Fmoc Chemistry (Ansynth, Roosendaal, the Netherlands), inhibits free light chain
activity but "does not interfere with IgE-or IgG-mediated mast cell activation.
The light chains
of primary amyloidosis are predominantly lambda, in contrast to the kappa light chains
seen in LCDD.
Immunoglobulins, produced by plasma cells and B lymphocytes, are built of two identical heavy and light chains
and these light chains
comprise one of two subtypes, known as kappa ([kappa]) and lambda ([lambda]).