light chain nephropathy

light chain disease

A nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.

Clinical findings
Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition.

light chain nephropathy

Nephrology A condition characterized by deposition of monoclonal light chains and electron-dense material in tubular and glomerular basement membranes Clinical Anorexia, nausea, weight loss, anemia, ↑ creatinine, ESRD; LCN may accompany myeloma
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References in periodicals archive ?
Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathy. Eur J Med Res.
El fracaso renal agudo por mieloma multiple: cuidados de los pacientes en una unidad de hemodialisis
Multiple myeloma presenting as dense deposit disease: light chain nephropathy. Nephron.
Renal lesions associated with plasma cell dyscrasias: practical approach to diagnosis, new concepts, and challenges
Patients with multiple myeloma and light chain nephropathy have Hb levels about 0.5 g/dL lower and require an Epoetin alfa dose 69% higher than those without the disease (Figure 2) (USRDS, 2003).
Increased risk of anemia in dialysis patients with comorbid diseases

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