light chain disease


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Related to light chain disease: kappa light chain, LCDD

light chain disease

A nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.

Clinical findings
Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
These laboratory findings--small or absent M-spike on SPEP and monoclonal light chain only on UPEP and immunofixation--are also consistent with light chain disease. Serum free light chain assays may detect increased concentrations of light chains in the serum but do not establish their monoclonality and cannot differentiate between light chain disease and IgD or IgE myeloma.
Since immunofixation for IgD is not routinely performed many cases are misdiagnosed as light chain disease (5).
This assay, which first became commercially available in 2001, is used to diagnose and monitor light chain myeloma, primary amyloidosis, and related light chain diseases. Despite the usually quoted high clinical sensitivity of serum FLC assay in detecting light chain disease, results within reference intervals can occur with intact immunoglobulin paraproteinemia (3).