light chain deposition disease

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light chain disease

A nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.

Clinical findings
Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition.

light chain deposition disease

Bence-Jones myeloma, light chain disease Oncology A paraproteinemia linked to renal amyloidosis, which occurs in 20% of Pts with immunoproliferative disorders; both are characterized by deposits of fibrillar and nonfibrillar monoclonal light chains in various tissues Clinical Rapidly progressive renal failure due to renal tubular blockage by Bence-Jones proteins, nephrotic syndrome, heart failure, arrhythmias, liver disease, neurologic disease; similar clinical findings are associated with heavy chain deposition
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References in periodicals archive ?
Systemic light chain deposition disease presenting as multiple pulmonary nodules: a case report and review of the literature.
Light chain deposition disease is histologically indistinguishable from nodular pulmonary amyloidosis; however, Congo red staining is negative (not shown) (hematoxylin-eosin, original magnifications x20 [A] and x400 [B]).
Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome.
Light chain deposition disease presenting with hepatomegaly: an association with amyloid-like fibrils.
9-11,42,43) Our understanding of light chain deposition disease is far more advanced than that of heavy chain deposition disease.
Among the glomerular expressions, "minimal" change, mesangioproliferative (Figure 8), membranoproliferative, and crescentic patterns have been documented in light chain deposition disease.
kappa]4 is overrepresented in light chain deposition disease.
Non-invasive diagnosis of light chain deposition disease.
We used urine samples obtained from inpatients with multiple myeloma (n = 9), benign monoclonal gammopathy (n = 1), primary macroglobulinemia (n = 1), light chain deposition disease (n = 1), and primary amyloidosis (n = 5).
3 105 (a) IEP, immuncelectrophoresis; MM, multiple myeloma; ND, not detected; BMG, benign monoclonal gammopathy; PMG, primary macroglobulinemia; LCDD, light chain deposition disease.