light chain


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Related to light chain: Myosin light chain kinase

chain

 [chān]
a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.
branched chain an open chain of atoms, usually carbon, with one or more side chains attached to it.
closed chain several atoms linked together so as to form a ring, which may be saturated, as in cyclopentane, or aromatic, as in benzene.
H chain (heavy chain) any of the large polypeptide chains of five classes that, paired with the L or light chains, make up the antibody molecule of an immunoglobulin; heavy chains bear the antigenic determinants that differentiate the classes of immunoglobulins. See also heavy chain disease.
J chain a polypeptide occurring in polymeric IgM and IgA molecules.
L chain (light chain) either of the two small polypeptide chains (molecular weight 22,000) that, when linked to H or heavy chains by disulfide bonds, make up the antibody molecule of an immunoglobulin monomer; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
open chain a series of atoms united in a straight line; components of this series are related to methane.
chain reaction a chemical reaction that is self-propagating; each time a free radical is destroyed a new one is formed.
side chain a group of atoms attached to a larger chain or to a ring.

light chain

a polypeptide chain of low molecular weight, such as the κ or λ chains in immunoglobulin. There are two identical κ- or λ-light chains in each immunoglobulin monomer.
Synonym(s): L chain

light chain

n.
The smaller of the two types of polypeptide chains in immunoglobulins, consisting of an antigen-binding portion with a variable amino acid sequence, and a constant region with an amino acid sequence that is relatively unchanging.

light chain (L chain)

immunoglobulin subunit of about 22,000 daltons molecular weight. Compare to heavy chain.

light chain

(līt chān)
A polypeptide chain with low molecular weight, as the κ or λ chains in immunoglobulin.

light chain

see IMMUNOGLOBULIN.

chain

a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.

chain binomial model
model of an outbreak of an infectious disease in which the outbreak is depicted as a series of steps with a binomial statement of the probability of an outcome at each step.
branched chain
an open chain of atoms, usually carbon, with one or more side chains attached to it.
heavy chain
any of the large polypeptide chains of five classes that, paired with the light chains, make up the antibody molecule. Heavy chains bear the antigenic determinants that differentiate the immunoglobulin classes. See also heavy-chain disease.
J chain
a polypeptide occurring in polymeric IgM and IgA molecules.
light chain
either of the two small polypeptide chains (molecular weight 22,000) that, when linked to heavy chains by disulfide bonds, make up the antibody molecule; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
light chain disease
the overproduction of immunoglobulin light chain molecules by certain B cell tumors (plasmacytomas). See monoclonal gammopathy.
obstetric chain
used in obstetrics in cattle and horses to snare extremities and for traction. Made of rustproof metal with links designed not to kink or to jam. They have a loop link at each end to facilitate single-handed formation of a loop. The links are shaped so that the ring-grip handles used for traction will grip at any point and stay put with the strongest pull.
chain shank
a leather lead with a short section of chain at the proximal end. It can be placed over the horse's nose, through the mouth or across the upper gum for greater control.
side chain
a chain of atoms attached to a larger chain or to a ring.
stallion chain
strong chain, 1-2 ft (0.5 m) long, at the end of a solid lead. For leading a stallion with little chance of his biting through the lead.
chain termination method
References in periodicals archive ?
We also evaluated Ig light chain concentrations with respect to immunoglobulin levels.
Keep score of how many times your light chain lit up as you traveled from one end to the other.
Rare conditions in which sheets of macrophages contain eosinophilic inclusions other than immunoglobulin light chain have also been called CSH, although in our view the term CSH may not be appropriate in these circumstances.
The assay for serum free light chain showed increased [kappa] light chains (300 mg/L) and decreased [lambda] light chains (<0.
A subtype of myeloma is light chain myeloma, where only immunoglobulin light chains are expressed, and a serum free monoclonal light chain analysis can quantify the exact amount.
Both monoclonal IgG-[lambda], and free lambda light chains were detected in her urine.
They are characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains.
2+]--CaM complex formation, which binds to and activates myosin light chain kinase (MLCK) (Horowitz et al.
The other strain's YAC carried genes for a human antibody light chain.
Millennium: The Takeda Oncology Company with its parent company Takeda Pharmaceutical Company Limited (TSE:4502) today announced the initiation of an international phase 3 clinical trial evaluating once-weekly oral MLN9708 plus dexamethasone in patients with relapsed or refractory light chain AL amyloidosis.
6) Burkitt lymphoma is characterized by translocation involving MYC at 8q24 with one of several partners, including the immunoglobulin heavy chain gene at 14q32, the [kappa] light chain gene at 2p12, or the [lambda] light chain gene at 22q11.