Indisulam is a small molecule that works by guiding the cells ubiquitin ligase
system to degrade a novel substrate, the RNA splicing factor RBM39.
2015) Protein neddylation: beyond cullin-RING ligases
Keap1 functions as an adaptor protein for the regulation of proteasomal degradation of Nrf2 by Cul3-dependent E3 ligase
After trying T4 DNA ligases
from different vendors, we decided to use highly concentrated enzyme (10 Weiss units/[micro]L) (23) provided by Epicentre.
Numerous deubiquitylases and ligases
have been identified as therapeutic targets for the discovery of drugs to treat a variety of diseases.
Dr Weissman has an excellent track record in ubiquitin ligases
biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA.
To achieve this, polymerases and ligases
used in traditional library preparations must be optimized to bind to minimal amounts of genomic input.
23 December 2009 - US clinical-stage drug development company Rigel Pharmaceuticals Inc (NASDAQ: RIGL) said today it has received a milestone payment from Japanese Daiichi Sankyo Co Ltd (TYO: 4568) as part of their collaboration to research and develop cancer treatments aimed at selectively inhibiting ligases
, which are intrinsic to cancer cell growth and proliferation.
The assay platforms will aid in the identification and further characterization of the approximately 100 DUBs and 700 ligases
in the human genome.
Objective: Specificity in the ubiquitin-proteasome system is largely conferred by ubiquitin E3 ligases
The AIR Small RNA Sequencing Kit includes AIR Ligase
, an enhanced enzyme that allows greater sequencing coverage than currently available T4 RNA ligases
Cognia's first database, Cognia Ubiquitin Database, a comprehensive summary of E3 ligases
and other Ubiquitin Proteasome Pathway proteins, is being launched later this month; a second already is in production and will be announced shortly.