ligase


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ligase

 [li´gās, lig´ās]
any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.
DNA ligase either of two enzymes that join two double-helical molecules of DNA together to make a longer DNA molecule.
ligase chain reaction a type of DNA amplification that uses DNA ligase to link chains and amplify the template containing the sequence in question.

li·gase

(lī'gās),
Generic term for enzymes (EC class 6) catalyzing the joining of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar compound.
See also: synthetase.

ligase

(lī′gās′, -gāz′)
n.
Any of a class of enzymes that catalyze the linkage of two large molecules.

li·gase

(lī'gās)
Generic term for enzymes (EC class 6) catalyzing the joining of two molecules coupled with the breakdown of a pyrophosphate bond in adenosine triphosphate or a similar compound.
See also: synthetase

ligase

An ENZYME that promotes the linkage of chemical groups. Also known as a synthetase.

ligase

an enzyme that catalyses the joining of short molecules into longer ones, for example, DNA LIGASE.
References in periodicals archive ?
Shankar et al., "Regulation of mitophagy by the Gp78 E3 ubiquitin ligase," Molecular Biology of the Cell, vol.
Dai et al., "Human HRD1 Is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum," The Journal of Biological Chemistry, vol.
An extraordinary example of the variability of UPS function in dendritic morphogenesis is the E3 ligase Mind bomb-1 (Mib1).
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
Zhang et al., "Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins," The Journal of Biological Chemistry, vol.
TNFAIP3 is a ubiquitin-editing enzyme that participates in ubiquitin ligase and deubiquitinase activities.
To test whether Hbo1 alone has ubiquitin E3 ligase activity, an array of E2 ubiquitin conjugating enzymes for self-ubiquitination of commercial Hbo1 protein were screened by mixing commercial recombinant Hbo1 protein with E1, E2, ATP, and biotinylated ubiquitin and probing with Cy5-conjugated streptavidin (Fig.
The glutamate-cysteine ligase modifier subunit (GCLM) and the glutamate-cysteine ligase catalytic subunit (GCLC) form the glutathione cysteine ligase (GCL) that catalyzes the conversion of glutamate and cysteine into y-glutamyl cysteine, a glutathione precursor [4].
Located at the N-terminal region of pCAF, lies a domain containing ubiquitin E3 ligase activity [23].
Tomkinson, "The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase," Nucleic Acids Research, vol.
These results suggested that siRNA-mediated knockdown of PIASy inhibited the sumoylation of IKK[gamma] and the activation of NF-[kappa]B inflammatory signaling; in other words, the SUMO E3 ligase PIASy plays an important role in the activation of NF-[kappa]B signaling induced by high glucose.