The identity of glutathione S-transferase B with ligandin
, a major binding protein of liver.
He was awarded a DSc (Med) from UCT in 1993 for his work on metabolic and clinical aspects of liver disease and especially for his work on ligandin
and fibrinogen metabolism.
Mutasyonlar kinaz aktivitesini bozarak, ligandin
baglanmasini engelleyerek ve heterodimerik dimer olusumuna etki ederek BNP sinyal yolunda kesintiye neden olurlar.
Bunun disinda B hucre farklilasmasinda rol oynayan koreseptorler CD27 ve CD134 ligandin
ekspresyonunda defektler vardir.
Today, it is known that both Bz2 and An9 GSTs are flavonoid-binding proteins (see Ligandin functions of GSTs in Plants) which are involved in the intracellular binding and stabilization of flavonoids (Mueller et al.
Beside their ligandin functions, GSTs have another nonconjugating activity, as catalyzing the nucleophilic attack of GSH on electrophilic oxygen and reduction of cytotoxic hydroperoxides to the less-toxic monohydroxy alcohols.
Since its isolation and identification as ligandin
, glutathione S-transferase (GST) has evolved as a suitable biomarker in the pretransplantation assessment of machine-perfused NHBD kidneys.
Quantification of human serum ligandin