ligandin

glu·ta·thi·one S-·trans·fer·ase

a class of enzymes that catalyzes the reaction of glutathione with an acceptor molecule (for example, an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.
Synonym(s): ligandin
References in periodicals archive ?
A delay in the bilirubin uptake may also be a response/ indication to the absence of thyroid hormones, which occurs due to the maturational changes in Ligandin. [19]
However, in this study, the authors suggest that the null GSTM1 genotype may affect ligandin functions in hepatocytes, which are important in bilirubin transportation and therefore, patients with the null GSTM1 genotype might have elevated levels of bilirubin [53].
Neonatal physiologic jaundice can be a result of increased bilirubin production secondary to accelerated destruction of erythrocytes or decreased excretory capacity secondary to low levels of ligandin which is a binding protein for bilirubin in hepatocytes and low activity of bilirubin-conjugating enzyme uridine diphosphoglucuronyltransferase (UDPGT).
Increased incidence of neonatal hyperbilirubinemia in preterm and low birth weight babies can be explained on the basis of hepatic immaturity, increased bilirubin load, decreased synthesis of ligandin (Y protein) and decreased UDPG (T) activity.
Jakoby, "The identity of glutathione S transferase B with ligandin, a major binding protein of liver," Proceedings of the National Academy of Sciences of the United States of America, vol.
Fleischner, "The identity of glutathione S transferase B with ligandin, a major binding protein of liver," Proceedings of the National Academy of Sciences of the United States of America, vol.
Impaired hepatic bilirubin clearance due specifically to reduced uptake or possible competition for binding to 2-protein or ligandin (Lee and Garner, 1983).
Intracellular transport of bilirubin from the hepatic plasma membrane to the endoplasmic reticulum, where conjugation occurs, is not well understood; however, cytosolic proteins (Y or ligandin Z or fatty-acid-binding protein) account for most of the intracellular bilirubin binding capacity.
He published in such fields as the modelling and regulation of protein metabolism, 'ligandin' and the glutathione transferases, the role of fibrin(ogen)-derived products in disease, angiotensin-converting enzyme, viral hepatitis, hepatic iron and liver injury, portal hypertension and porphyria.
Mutasyonlar kinaz aktivitesini bozarak, ligandin baglanmasini engelleyerek ve heterodimerik dimer olusumuna etki ederek BNP sinyal yolunda kesintiye neden olurlar.
Bunun disinda B hucre farklilasmasinda rol oynayan koreseptorler CD27 ve CD134 ligandin ekspresyonunda defektler vardir.