Neonatal physiologic jaundice can be a result of increased bilirubin production secondary to accelerated destruction of erythrocytes or decreased excretory capacity secondary to low levels of ligandin
which is a binding protein for bilirubin in hepatocytes and low activity of bilirubin-conjugating enzyme uridine diphosphoglucuronyltransferase (UDPGT).
Increased incidence of neonatal hyperbilirubinemia in preterm and low birth weight babies can be explained on the basis of hepatic immaturity, increased bilirubin load, decreased synthesis of ligandin
(Y protein) and decreased UDPG (T) activity.
The identity of glutathione S-transferase B with ligandin
, a major binding protein of liver.
Impaired hepatic bilirubin clearance due specifically to reduced uptake or possible competition for binding to 2-protein or ligandin
(Lee and Garner, 1983).
Intracellular transport of bilirubin from the hepatic plasma membrane to the endoplasmic reticulum, where conjugation occurs, is not well understood; however, cytosolic proteins (Y or ligandin
Z or fatty-acid-binding protein) account for most of the intracellular bilirubin binding capacity.
He was awarded a DSc (Med) from UCT in 1993 for his work on metabolic and clinical aspects of liver disease and especially for his work on ligandin
and fibrinogen metabolism.
Mutasyonlar kinaz aktivitesini bozarak, ligandin
baglanmasini engelleyerek ve heterodimerik dimer olusumuna etki ederek BNP sinyal yolunda kesintiye neden olurlar.
Bunun disinda B hucre farklilasmasinda rol oynayan koreseptorler CD27 ve CD134 ligandin
ekspresyonunda defektler vardir.
Expression of Fas ligand and sFas ligandin
human gastric adenocarcinomas.
Today, it is known that both Bz2 and An9 GSTs are flavonoid-binding proteins (see Ligandin
functions of GSTs in Plants) which are involved in the intracellular binding and stabilization of flavonoids (Mueller et al.
Since its isolation and identification as ligandin
, glutathione S-transferase (GST) has evolved as a suitable biomarker in the pretransplantation assessment of machine-perfused NHBD kidneys.
Quantification of human serum ligandin