ligand-binding site

lig·and-bind·ing site

the site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme.
Farlex Partner Medical Dictionary © Farlex 2012

li·gand-bind·ing site

(lī'gand-bīnd'ing sīt)
The site on the surface of a protein that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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Amino acids 123-427 constitute the VDR LBD with R274 being the ligand-binding site located in helix H5 that makes contact with the 1[alpha]-hydroxyl group of 1,25(OH)2D3 [7].
GSTs consist of a specific-glutathione (GSH)-binding site (G-site) next to a non-specific electrophilic ligand-binding site (H-site).
The COFACTOR, a structure-based method for biological function annotation of protein molecules, was used to identify the functional insights including ligand-binding site, gene-ontology terms, and enzyme classification [37-39].
Other CRP ligands relevant to cardiovascular disease--such as nuclear autoantigens, apoptotic cells, and lipoproteins--have also been identified (1), but binding to most of these ligands also requires [Ca.sup.++] and can be inhibited by phosphocholine, indicating that the single promiscuous ligand-binding site on the B face can accommodate diverse structural groups.
Cetuximab is a monoclonal antibody, binding to the ligand-binding site of EGFR and blocking its dimerization and activation.
METHODS: We performed computational modeling to determine interaction energies between the ligand and the AR ligand-binding site, and measured in vitro competitive binding assays for AR by polarization fluorometry analysis.
Lipocalins have a conserved folding pattern consisting of antiparallel [beta]-strands that form a [beta]-barrel with a distinct ligand-binding site. This lab recently determined the high resolution (1.2 [Angstrom]) X-ray crystal structure of recombinant human C8[gamma] produced in insect cells.
EGFR is a transmembrane protein composed of an extracellular region containing the ligand-binding site, a transmembrane [alpha]-helix, and an intracellular region harboring the tyrosine kinase domain, that is, flanked by a juxtamembrane domain (JM) and a C-terminal tail.
The identification of putative ligand-binding sites on proteins is important for the prediction of protein function.
This type of response would be expected if hER possesses multiple ligand-binding sites displaying cooperative behavior as has been reported (14,16).