PCR-based metagenomic library screening
for PKS genes
They address the core methodology used in computational drug discovery and selected applications, including the physical basis of ligand binding, the force field representation of biomolecular systems, and the concepts of chemical library representation and design, fragment libraries, drug-likeness, and filtering, as well as major in silico methods, such as ligand-based chemical library screening
, pharmacophore modeling and screening, and ligand-protein docking.
Qazi Hamed from RX Biosciences Limited, US spoke about the current trends in the rapidly evolving surface display technology which is a popular tool for protein engineering and library screening
The Oxnard Public Library screening
will be the first time viewers will be able to see the entire second episode of Things Left Unsaid, which was crowdfunded using IndieGoGo last year.
Matthew Frieman of the University of Maryland Medical School said repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to the normal paradigm of huge library screening
against a specific viral enzyme.
Seven years after its launch, the Dubai Film Market is steadily reinforcing its role as the Arab world's prime film business hub, with more movies than ever--some 400 from the Gulf region and elsewhere--unspooling in its Cinetech video library screening
series this year.
Following is coverage of enzyme reaction mechanisms, reversible modes of inhibitor interactions with enzymes, assay considerations for compound library screening
, lead optimization and structure-activity relationships for reversible inhibitors, slow binding inhibitors, tight binding inhibition, drug-target residence time, irreversible enzyme reactions, and quantitative biochemistry in the pharmacological evaluation of drugs.
According to the companies, the ability to generate iPS cell lines from different patients and from normal donors could enable researchers to address disease targets and develop therapeutics, both by comparative genetic screening as well as by traditional compound library screening
The system achieves optimal analytical speed by multiplexing proprietary fast Microflow liquid chromatography technology, delivering results sooner for high throughput applications such as library screening
and analytical method development.
Among their topics are gel permeation chromatography spin columns coupled with ESI-MS, library screening
using ultra-filtration and mass spectrometry, and fragment-based drug discovery.
These systems have become very useful in compound library screening
, well-plate reformatting and assay development.
Specifically, Rigel was granted six patents in immunology, five patents related to its ubiquitin ligase technology, four patents related to hepatitis-C (HCV), six patents in oncology, four patents towards its library screening
technology, and four patents in Fluorescence- Activated Cell Sorter (FACS) technology.