levosimendan


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levosimendan

Simdax® Cardiology A calcium-sensitizing agent which ↑ heart pump efficiency w/o ↑ O2 consumption or causing arrhythmias
References in periodicals archive ?
M2 PHARMA-March 6, 2018-Tenax Therapeutics Preclinical Studies Show Levosimendan Improves Right Heart Function
Tenax Therapeutics announced the publication of a positive preclinical study of levosimendan conducted by Hansen et al in the March 1, 2018, issue of Pulmonary Circulation.
Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass.
M2 EQUITYBITES-November 21, 2016-Tenax Therapeutics concludes patient enrollment in Phase 3 LEVO-CTS trial of levosimendan in cardiac surgery
For these reasons, all anti-apoptotic treatment modalities such as a Ca-sensitiserinotropic agent levosimendan, caspase and/or Poly (ADP-ribose) polymerase (PARP) inhibition, inhibition of Bax using antisense technology, adenine nucleotide transporter (ANT) antibodies, gap junction and microtubule inhibitors in the treatment of myocardial ischaemia/ reperfusion injury can individually exert beneficial therapeutic effects.
Levosimendan prevents the reduction of O2 transport and acidosis of the intestinal mucosa in experimental sepsis models.
It includes milrinone, tolvaptan, nesiritide, levosimendan, tezosentan, low-dose dopamine, and ultrafiltration.
Caracteristicas generales de los pacientes Variable Recuento (%) Genero Femenino 7 (21,2) Masculino 26 (78,8) Euro score Riesgo bajo 10 (30,3) Riesgo intermedio 11 (33,3) Riesgo alto 12 (36,4) Tipo de cirugia Revascularizacion miocardica 17 (51,5) Cambio valvular 10 (30,3) Endarterectomia pulmonar 2 (6,1) Recambio valvular + Reemplazo aorta 3 (9,1) Revascularizacion + Remodelacion ventricular 1 (3) FeVI Mayor 50% 16 (48,5) Menor 50% 17 (51,5) Cirugia cardiovascular previa 4 (12,1) EPOC 7 (21,2) ASA 33 (100) Clopidogrel 15 (45,5) Warfarina 7 (21,2) Recibio dobutamina 32 (97) Recibio levosimendan 15 (45,5) Recibio milrinone 17 (51,5) Arresto cardiaco 2 (6,1) Causa de reintervencion Sangrado anormal 12 (36,4) Taponamiento 23 (69,7) Variables cualitativas.
Es controvertido el uso de inotropicos simpaticomimeticos, por la posibilidad de empeorar el cuadro y la obstruccion del tracto de salida, por lo que se prefiere milrinone o levosimendan, y si es necesario el uso del balon de contrapuisacion intraaortico.
Newer drugs such as bromocriptine [4] and levosimendan [5] have been tried in the treatment of this condition but with limited success.