levodopa-carbidopa

levodopa-carbidopa

(lev´ōdō´pə-kar´bidō´pə),
n brand names: Sinemet, Sinemet CR;
drug class: antiparkinson agent;
action: decarboxylation of levodopa to periphery is inhibited by carbidopa; more levodopa is made available for transport to brain and conversion to dopamine in the brain;
uses: treatment of idiopathic, symptomatic, or postencephalitic parkinsonism.
References in periodicals archive ?
Contract award notice: Suministro de Medicamentos, levodopa-carbidopa, ritonavir y palivizumab.
There are several side effects of levodopa-carbidopa (Sinemet, Parcopa, Atamet).
Medications such as levodopa-carbidopa and DAs help to provide symptomatic relief and delay the progression of PD but are not effective indefinitely.
A levodopa-carbidopa gel for treating Parkinson's disease has been submitted for FDA approval.
10 June 2011 - US Abbott (NYSE: ABT) said on Thursday that interim efficacy and safety results from a long-term, 54-week, Phase III open-label study of its investigational treatment for advanced Parkinson's disease showed that patients treated with levodopa-carbidopa intestinal gel (LCIG) for 12 weeks reported a decrease in "off" time and an increase in "on" time without troublesome dyskinesias.
Postural hypotension can occur in older adults taking MAO-B inhibitors with levodopa-carbidopa (Chen & Ly, 2006).
Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations.
Although levodopa-carbidopa restores normal movement early in the disease's course, the treatment loses effectiveness as the disease progresses (wearing-off effect).
Additionally, most patients progressed to Azilect from generic levodopa-carbidopa fixed-dose combinations, with the majority of these patients adding Azilect to levodopa-carbidopa therapy.
Parkinsons Disease: A therapy that is a once-daily, transdermal formulation of levodopa-carbidopa