levodopa


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Related to levodopa: carbidopa, dopamine, Sinemet

levodopa

 [le″vo-do´pah]
l-dopa, the levorotatory isomer of dopa; used in treatment of parkinson's disease and other forms of parkinsonism, administered orally.

le·vo·do·pa

(lē'vō-dō'pă),
The biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): l-dopa

levodopa

(lē′və-dō′pə)
n.
See L-dopa.

levodopa

Neuropharmacology The l- isomer of dopa, which is converted in vivo into dopamine, and used as a first-line anti-Parkinsonian agent Therapeutic range 0.2–0.3 µg/mL

le·vo·do·pa

(l-dopa) (lē'vō-dō'pă)
The biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): laevodopa.

levodopa

L-dopa. A drug used in the treatment of PARKINSON'S DISEASE. Levodopa relieves symptoms in the majority of cases and often effects a remarkable reduction in disability. Brand names of the drug, in combination, respectively, with benserazide and carbidopa, are Madopar and Sinemet.

Levodopa (L-dopa)

A substance used in the treatment of Parkinson's disease. Levodopa can cross the blood-brain barrier that protects the brain. Once in the brain, it is converted to dopamine and thus can replace the dopamine lost in Parkinson's disease.
Mentioned in: Movement Disorders

le·vo·do·pa

(lē'vō-dō'pă)
Biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): l-dopa, laevodopa.
References in periodicals archive ?
Tal controversia pode estar associada ao tipo clinico (sintoma predominante) da DP, pois a diversidade e divergencias de resultados encontrados em relacao a resposta da disfagia na DP apos a terapia com Levodopa, que pode ter ocorrido pela nao consideracao de tais sintomas clinicos predominante na amostra estudada, visto que tais sintomas podem apresentam diferentes respostas a medicacao.
Antonini and Barone (2008) suggested a treatment algorithm starting with a dopamine agonist or MAO-B inhibitor for first-line therapy, except in the older adult or a patient with cognitive impairment, and then adding levodopa as a second-line drug.
Waters also addressed the 10-year results of a ropinirole versus levodopa study (Mov.
Catechol-O-methyltransferase (COMT) inhibitors are taken in conjunction with levodopa to block the COMT enzyme that degrades levodopa in the periphery, thus allowing greater quantities to cross the blood brain barrier.
Patients with early Parkinson's are prescribed levodopa, dopamine agonists or MAOB inhibitors, while those with later Parkinson's who have motor complications that are uncontrolled by their existing drug therapy will be given one of the other drugs as follow-on treatment.
In patients with advanced disease, there is amino acid competition for levodopa absorption, which can cause erratic responses to levodopa (Nutt, Woddard, Hammerstad, Carter, & Anderson, 1984).
'Avoiding exposure to levodopa should reduce the risk of developing motor complications, which are believed to be a consequence of long-term use of levodopa,' the researchers noted.
The conclusions should not prevent people from using levodopa, he added.
Levodopa is the most potent anti-Parkinson's drug available.
Initially, 301 patients were randomized to receive pramipexole and placebo 1evodopa or levodopa and placebo pramipexole.
They then had baseline observations of tapping and walking before receiving a test dose of levodopa 100 mg and carbidopa 25 mg with domperidone 20 mg to prevent nausea and vomiting.
In the early stages of Parkinson's disease, physicians often begin treatment with one or a combination of the less powerful drugs--such as the anticholinergics or amantadine (see section entitled "Are There Other Medications Available for Managing Disease Symptoms?"), saving the most powerful treatment, specifically levodopa, for the time when patients need it most.