levodopa


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Related to levodopa: carbidopa, dopamine, Sinemet

levodopa

 [le″vo-do´pah]
l-dopa, the levorotatory isomer of dopa; used in treatment of parkinson's disease and other forms of parkinsonism, administered orally.

le·vo·do·pa

(lē'vō-dō'pă),
The biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): l-dopa

levodopa

/le·vo·do·pa/ (-do´pah) -dopa; the levorotatory isomer of dopa, used as an antiparkinsonian agent.

levodopa

(lē′və-dō′pə)
n.
See L-dopa.

levodopa

[lē′vōdō′pə]
an antiparkinsonian agent.
indications It is prescribed in the treatment of Parkinson's disease, juvenile forms of Huntington's disease when rigidity is the main feature, and chronic manganese poisoning (which can lead to Parkinson-like symptoms in welders).
contraindications Narrow-angle glaucoma, concomitant use of a monoamine oxidase inhibitor, suspected melanoma, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are severe GI disturbances, hypotension, various movement disorders, emotional changes, cardiac arrhythmia, and anorexia.

levodopa

Neuropharmacology The l- isomer of dopa, which is converted in vivo into dopamine, and used as a first-line anti-Parkinsonian agent Therapeutic range 0.2–0.3 µg/mL

le·vo·do·pa

(l-dopa) (lē'vō-dō'pă)
The biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): laevodopa.

levodopa

L-dopa. A drug used in the treatment of PARKINSON'S DISEASE. Levodopa relieves symptoms in the majority of cases and often effects a remarkable reduction in disability. Brand names of the drug, in combination, respectively, with benserazide and carbidopa, are Madopar and Sinemet.

Levodopa (L-dopa)

A substance used in the treatment of Parkinson's disease. Levodopa can cross the blood-brain barrier that protects the brain. Once in the brain, it is converted to dopamine and thus can replace the dopamine lost in Parkinson's disease.
Mentioned in: Movement Disorders

levodopa

dopamine precursor, used to treat Parkinson's disease; dose benefit progressively reduces; may induce peripheral neuropathy

le·vo·do·pa

(lē'vō-dō'pă)
Biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): l-dopa, laevodopa.

levodopa

(lev´ōdō´pə),
n brand names: Larodopa, Dopar;
class drug: antiparkinson agent;
action: levodopa is decarboxylated to dopamine, which can interact with dopamine receptors;
uses: parkinsonism or parkinsonian symptoms.

levodopa, L-DOPA

the pharmaceutical name for dopa.
References in periodicals archive ?
13) There was no difference in mortality between patients initially treated with bromocriptine vs levodopa.
PD gait during the 'off' phase' of the levodopa medication cycle
Monoamine oxidase-B (MAO-B) inhibitors are another alternative to levodopa for treating early Parkinson's disease.
That similarity suggests that the length of levodopa use doesn't influence the severity of its side effects.
23] apresentaram desenho de estudo semelhante, avaliaram a degluticao em pacientes com DP de ambos generos, com medias de idade equivalentes (60-70 anos), utilizaram como instrumento de avaliacao da degluticao a videofluoroscopia (VF), separaram a amostra em dois grupos considerando tipos clinicos diferentes e realizaram os exames na condicao "on" e "off', visando comparar as diferencas entre grupos e as respostas destes a terapia com Levodopa.
Possible side effects Levodopa can cause dizziness and drowsiness, so use caution when driving.
However, patients taking dopamine agonists with or without levodopa experienced significantly more adverse effects than patients taking levodopa alone.
The challenge will be to target and block the right nerve cells in the brain which cause dyskinesia, without interfering with the positive benefits of levodopa.
Levodopa provides relief for the motor symptoms of PD within 1530 minutes of administration.
In the Comparison of the Agonist Pramipexole With Levodopa on Motor Complications of Parkinson's Disease, Dr.
At this stage many neurologists would consider that addition of levodopa to the treatment regimen is an appropriate step.
We welcome today's news flow as it provides strong supportive evidence that ADX10059 has the potential to lower side effects from levodopa treatment of mid- to late-stage Parkinson's disease patients," said Olav Zilian, analyst at Swiss brokerage Helvea.