A comparison of the analgesic efficacy of 0.25% levobupivacaine
combined with 0.005% morphine, levobupivacaine
alone or 0.005% morphine alone for the management of postoperative pain in patients undergoing major abdominal surgery.
yielded less mean VAS score at rest and at movement compared to control group at all-time points (P, 0.02) and the rescue analgesic consumption was greater in control group.
In another study using a different active ingredient evaluated the efficacy of levobupivacaine
in PPNB injection and showed that this agent provided better pain control compared to a diclofenac suppository alone (20).
Various local anesthetics commonly used for spinal anesthesia are lignocaine, bupivacaine, levobupivacaine
, and ropivacaine23.
Dexmedetomidine added to levobupivacaine
prolongs axillary brachial plexus block.
In a study with adult patients undergoing tonsillectomy and uvulopalatopharyngoplasty (UPPP), effect of bupivacaine has been investigated and it was recommended to be used for pain reduction in intraoral surgeries.21 A study showed that levobupivacaine
was more effective on postoperative pain and intraoperative bleeding compared to saline.22 Bupivacaine is a local anaesthetic belonging to amino amide group which inhibits access of sodium to the nerve cells, preventing depolarisation.
Three mean pressure values were compared in the group that received bupivacaine and the group that received levobupivacaine
prior to surgery, at the end of surgery, and the lowest pressure during the procedure, as well as three T-tests for independent samples.
A randomized clinical study comparing spinal anesthesia with isobaric levobupivacaine
with fentanyl and hyperbaric bupivacaine with fentanyl in elective cesarean sections.
Transcervical intrauterine levobupivacaine
or lidocaine infusion for pain control during endometrial biopsy.
It has been shown that various anesthetic agents used for periprostatic nerve blockage, such as articaine, bupivacaine, levobupivacaine
, ropivacaine, lignocaine and mainly lidocaine, provide effective analgesia (10,11,12,15,16,17).
Various single enantiomeric drugs such as levobupivacaine
and ropivacaine are now being used, with concerns regarding cardiac toxicity of racemic bupivacaine.