leukotriene receptor antagonist


Also found in: Acronyms.

leukotriene receptor antagonist

a class of agents, of which zileuton, montelukast, zafirlukast are the best known, used in the prophylactic and chronic treatment of asthma in older children and adults; these drugs are not bronchodilators in themselves, but act by interfering with the leukotriene-mediated inflammatory process present in asthma.

leukotriene receptor antagonist

Pharmacology Any of a family of agents used to treat asthma by interfering with the binding of leukotriene D4
References in periodicals archive ?
15 showed that intravenous leukotriene receptor antagonists could produce a 22% improvement in [FEV.
Randomized, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients.
The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria.
INV104 (zafirlukast) is a leukotriene receptor antagonist (LTRA) or anti- leukotriene that reduces inflammation, constriction of the airways, and the build-up of mucus in the lungs.
Even though all three patients were on prophylactic montelukast (Singulair) at the time of aspirin challenge, the leukotriene receptor antagonist may not provide complete protection in a subset of vulnerable patients.
Leukotrienes have been implicated in the pathogenesis of eustachian tube dysfunction, (1-4) and a leukotriene receptor antagonist has been shown to be beneficial in preventing the development of middle ear fluid after an inflammatory challenge in the guinea pig model.
Alternative--Cromolyn, leukotriene receptor antagonist, or theophylline (serum level 5-12 mcg/mL).
Asthma control in children with mild to moderate disease improved consistently and significantly more with an inhaled corticosteroid than with a leukotriene receptor antagonist in a recent multi center crossover trial.
Lofdahl CG, Reiss TF, Leff JA, et al: Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients.
Zeneca Pharmaceuticals also markets a leukotriene receptor antagonist under the brand name Accolate.
Focus on zafirlukast: A leukotriene receptor antagonist for the prophylaxis and chronic treatment of asthma.