In spite of many studies throughout the world, there are still much more pathophysiologic mechanisms to be uncovered and the current mainstream of medication still remains symptom control including bronchodilators such as [beta]2 agonists, inhaled and systemic corticosteroid, antihistamines, and leukotriene modifiers
, all only with transient symptomatic relief.
Current medications for asthma are effective and facilitate a multi-pronged approach, and include inhaled corticosteroids, long-acting bronchodilators (beta-agonists and anticholinergics), theophylline, leukotriene modifiers
, and more recent strategies such as the use of anti-immunoglobulin E (IgE) antibodies (omalizumab) and anti-IL-5 antibodies.
affect only one biochemical pathway--the lipoxygenase path and resulting leukotriene effects.
[USPRwire, Thu Oct 23 2014] Asthma accounts for approximately 250,000 deaths around the world annually, deaths that otherwise could be easily prevented through appropriate treatment The asthma market saw very slow growth over the past decade, as it has become saturated with relatively efficacious standard therapies, such as short-acting beta-agonists (SABAs), inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers
, and has also been facing increasing generic competition.
The second type are "control" or "preventive" medications (inhaled corticosteroids, long-acting beta-agonists, leukotriene modifiers
) and are taken daily even when there is no sign of asthma symptoms because these medications prevent symptoms and more severe attacks from occurring.
Studies using cysLTR1 antagonists and other leukotriene modifiers
have suggested that these agents maybe of benefit in patients with aspirin-intolerant asthma [125, 126].
are a form of anti-inflammatory medication that helps prevent asthma symptoms for up to 24 hours.
Patients were allowed to continue the use of stable doses of sustained-release theophylline, leukotriene modifiers
, anti-immunoglobulin E antibody, or oral glucocorticoids, and were given open-label inhalers of salbutamol or albuterol for use as rescue medication.
From these patients, the researchers looked for individuals who were new users of asthma controller medications, including inhaled corticosteroids, long-acting beta-agonists or leukotriene modifiers
, or IACs, and who had continuous enrollment in the IMS system for at least six months prior to having the control medication dispensed.
On the other hand, women were significantly more adherent than men were for leukotriene modifiers
If these cognitive symptoms bother you, speak to your health care provider, who may adjust dosage levels or suggest alternative drugs such as leukotriene modifiers
(Singulair; Zyflo), mast cell stabilizers (Crolom; Nasalcrom; Tilade), or the antibody omalizumab (Xolair), which prevents the release of inflammatory chemicals that narrow the airways.
The goalposts have changed recently with the addition of long-acting beta 2 agents such as salmeterol and the recent advent of leukotriene modifiers
. (6) This review highlights the update on their use.