Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin
. Microb Pathog 2002; 32:1-13.
bacteriovorus SSB218315 also encodes genes annotated as RTX toxins, a factor that has different biological functions such as pore-forming leukotoxin
, metalloprotease, and lipase activities .
find another periodontal germ called Aggregatibacter actinomycetemcomitans (Aa) can induce hypercitrullination in host neutrophils through its leukotoxin
Diols from Ground Corncob Bedding Disrupt Estrous Cyclicity in and Stimulate MCF-7 Breast Cancer Cell Proliferation.
intermedius) carry several virulence factors i.e coagulase, clumping factors, haemolysin and leukotoxin
, pyogenic toxins comprising staphylococcal enterotoxins, toxic shock syndrome toxin 1, and S.
Effects of Pasteurella haemolytica leukotoxin
on isolated bovine neutrophils.
A final example is a similar crossed reaction to the leukotoxin
of the A.
Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV Leukotoxin
 The pathogenicity of the microorganism is also underlined by its well-characterized virulence factors, such as leukotoxin
and cytolethal distending toxin, which are suggested to play important roles in altering host inflammatory responses as well as in contributing to periodontal disease progression.
Additional candidates have been highlighted in the literature, including the leukotoxin
LukED which targets the human CCR5 receptor (Alonzo, 2013).To ensure the development of efficacious and safe vaccine antigens, the research project proposes the structure-based optimization of two candidate antigens: (i) an antigen engineered from the Csa protein family that we recently discovered and characterized (Schluepen, 2013) and (ii) an engineered detoxified leukotoxin-E antigen.
Inhibition of PMN function.
Kato, "Interaction of Actinobacillus actinomycetemcomitans outer membrane vesicles with HL60 cells does not require leukotoxin
," Cellular Microbiology, vol.