leukoreduction


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leukoreduction

(loo″kō-rē-dŭk′shŭn) [Gr. leukos, white, + L. reductio, leading back]
The loss of white blood cells from a unit of packed red cells by filtration of the blood before transfusion. White blood cells in red cell transfusions have been associated with immunosuppression in recipients. Leukoreduction typically lowers the white cell content of packed red cells from about 3 × 109 per unit of blood to about 2.5 × 105 per unit. It has been associated with a decrease in post-transfusion fevers, and, in some studies, with decreased post-transfusion mortality.
References in periodicals archive ?
Red Cell Filter market is expected to mark significant growth over forecasted period owing to increasing consumers spending on Leucodepletion, Leukoreduction applications and technological advancement.
By product, the apheresis devices segment is expected to account for the largest share of the leukapheresis devices market in 2018 On the basis of type, the Leukapheresis Devices Market is segmented into apheresis devices, leukapheresis columns & cell separators, and leukoreduction filters.
phagocytophilum is found predominantly within granulocytes, leukoreduction lowers the risk of transfusion-transmitted anaplasmosis (TTA) by reducing the level of the organism by 300-fold (5).
Theoretically, leukoreduction (also known as leukodepletion or leukofiltration) could remove a sufficient number of white blood cells to limit TAGVHD; however, there have been 23 reported cases of TA-GVHD after transfusion of leukoreduced red blood cells in the literature, (39) indicating leukoreduction alone is not adequate to prevent TA-GVHD.
The risk of febrile reaction is reduced to 0.2 percent when patients receive prestorage leukoreduced blood products but increased to 2 percent for poststorage leukoreduction [18].
Whereas other studies have fabricated microfluidic devices as effective high-throughput leukoreduction filters [21], we incorporate these ceramic HFs into 3D porous scaffolds serving as a perfusion platform with continuous cell filtration harvest.
(8) in the Netherlands in this context identified non-leuco-reduction as being associated with increased incidence of multiorgan dysfunction, infection and length of hospital stay (8) resulting alongside other studies in the immediate initiation of the EU directive for pre-storage leukoreduction to be required for all banked blood.
Griffin et al., "Age of transfused blood: an independent predictor of mortality despite universal leukoreduction," The Journal of Trauma, vol.
The association of red cell transfusions with post-operative infections has been shown in randomized clinical trials to be partially mitigated by leukoreduction. (3,4) Restricting the transfusion of red cells to much lower levels of hemoglobin than previously thought ideal (< 7g/dl or hematocrit of < 21) also reduces the number of patients who develop HAIs.
Leukapheresis rapidly yields leukoreduction and is the initial treatment of hyperleukocytosis with symptoms.