leukoreduction


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leukoreduction

(loo″kō-rē-dŭk′shŭn) [Gr. leukos, white, + L. reductio, leading back]
The loss of white blood cells from a unit of packed red cells by filtration of the blood before transfusion. White blood cells in red cell transfusions have been associated with immunosuppression in recipients. Leukoreduction typically lowers the white cell content of packed red cells from about 3 × 109 per unit of blood to about 2.5 × 105 per unit. It has been associated with a decrease in post-transfusion fevers, and, in some studies, with decreased post-transfusion mortality.
References in periodicals archive ?
Despite continued debate, leukoreduction is considered by many to be adequate for TT-CMV mitigation for all patient populations.
8) in the Netherlands in this context identified non-leuco-reduction as being associated with increased incidence of multiorgan dysfunction, infection and length of hospital stay (8) resulting alongside other studies in the immediate initiation of the EU directive for pre-storage leukoreduction to be required for all banked blood.
Leukoreduction for the prevention of adverse reactions from allogeneic blood transfusion.
The association of red cell transfusions with post-operative infections has been shown in randomized clinical trials to be partially mitigated by leukoreduction.
Contract notice: Acquisition of integrated systems for harvesting bags and automatic separation of whole blood by centrifugation and simultaneous expression as well as systems for pooled platelets with integrated leukoreduction filter and use of additive solution, placement of appropriate equipment for this purpose in the service immuno-blood therapy for a period of 36 months.
Leukapheresis rapidly yields leukoreduction and is the initial treatment of hyperleukocytosis with symptoms.
In addition, incidence of transfusion-related reactions has decreased considerably due to prestorage leukoreduction.
Conducting new RCTs on the effects of leukocyte-containing RBCs in countries that implemented universal leukoreduction of blood products is not possible.
For example, to help streamline blood center operations, the new Auto RBC function automates the in-line leukoreduction of red blood cells (RBCs), which eliminates the need for lab processing with ready-to-store, leukoreduced RBC products.
The observational study was conducted during the seven years before and after 2000, when the URMC introduced universal leukoreduction, a process that filters the white cells from blood to be used for transfusions.
Since latent CMV is found in peripheral blood monocytes (7), there are a lot of studies that refer a decrease in the transmission of CMV by leukoreduction of blood components.
Other preventive strategies (such as leukoreduction filtration, saline-washed RBCs, frozen deglycerolised RBCs, etc.