Alpha-1 antitrypsin (AAT), secretory leukoprotease
inhibitor (SLPI) and elafin are the most abundant serine antiproteases in the lung.
Intracellular secretory leukoprotease
inhibitor can exert an anti-inflammatory effect on neutrophils of individuals with CF and COPD by inhibiting the excessive influx of neutrophil .
Kanerva et al., "The secretory leukoprotease
inhibitor (SLPI) promoter for ovarian cancer gene therapy," The Journal of Gene Medicine, vol.
Antiproteases such as [[alpha].sub.1]-proteinase inhibitor ([[alpha].sub.1]-PI) and secretory leukoprotease
inhibitor may be inactivated by ROS.
Among the various trypsin inhibitors tested, the natural airway inhibitor, secretory leukoprotease
inhibitor (SLPI), which is secreted from non-ciliated secretory airway Clara and goblet cells, (36),(37) and is found in bronchoalveolar lavage fluid and nasal and salivary secretion, efficiently suppresses proteolytic activation of IAV HA and viral multiplication.
[sup] Genes that are switched on by glucocorticoids include genes encoding b[sub]2 AR and the anti-inflammatory proteins secretory leukoprotease
inhibitor and mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), which inhibits MAPK pathways.
In the same issue of SCIENCE, they describe in vitro experiments using a recombinant form of a human protein known as secretory leukoprotease
inhibitor, or SLPI.
These cathepsins have been reported to cleave and inactivate antiprotease secretory leukoprotease
inhibitor (SLIP) of neutrophil-derived elastase, shifting delicate protease/antiprotease equilibrium toward proteolytic activity and increasing neutrophil extracellular trap (NET) formation and activity [39,40].