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Related to leukoplakia: leukoplakia vulvae


a disease marked by the development of white thickened patches on the mucous membranes of the cheeks (leukoplakia buccalis), gums, or tongue (leukoplakia lingualis); the patches sometimes form fissures and often become malignant. They may grow into larger patches or form ulcers. Those in the mouth may in time cause pain during swallowing of food or speaking. Leukoplakia affects mostly middle-aged to elderly men, often after prolonged irritation of the mouth from such varying factors as badly fitting dentures or immoderate use of tobacco.

Treatment is aimed at removing any possible cause of physical or chemical irritation; the patient should give up tobacco and possibly also alcohol and extremely hot food. Dental attention may be necessary if teeth are uneven or dentures do not fit properly. Surgical removal of the affected area is relatively simple and may be the best means of preventing further development of the condition.
oral hairy leukoplakia a white filiform to flat patch occurring on the tongue or, rarely, on the buccal mucosa, caused by infection with Epstein-Barr virus and associated with human immunodeficiency virus infection.
leukoplakia vul´vae the presence of hypertrophic grayish-white infiltrated patches on the vulvar mucosa; specific diagnosis is determined by biopsy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


A white patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, a clinical term without histologic connotation.
Synonym(s): smoker's patches
[leuko- + G. plax, plate]
Farlex Partner Medical Dictionary © Farlex 2012


(lo͞o′kə-plā′kē-ə) also


An abnormal condition characterized by white spots or patches on mucous membranes, especially of the mouth and vulva. Also called leukoplasia.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

leukoplakia (vulvar)

Chronic vulvar dystrophy, see there.  

The term leukoplakia continues to be widely used (incorrectly) in the working gynaecological parlance; the error lies in that the term leukoplakia merely refers to the macroscopic appearance of white patches in the postmenopausal vulva, which most commonly correspond to hyper- or parakeratosis and far less commonly to carcinoma in situ or Paget's disease. The portent of vulvar leukoplakia is thus in sharp contrast to oral leukoplakia, which is generally regarded as a pre-malignant lesion.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A potentially precancerous white patch or plaque on a mucosa characterized by epithelial hyperplasia and hyperkeratosis, often caused by chronic irritation; leukoplakia–LP affects the mucosa of oral cavity, upper respiratory tract, vulva, uterine cervix, renal pelvis, urinary bladder; in each site, the significance differs ENT Smoker's keratosis A white plaque or patch on the oral mucosa. See Hairy leukoplakia Ob/Gyn A white plaque or patch on the vaginal mucosa, seen without magnification or acetic acid, and often elevated from surrounding surfaces with a sharp border and Lugol's non-staining Histology Hyperkeratosis, possibly epithelial proliferation. See Speckled leukoplakia.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A white patch of oral mucous membrane that cannot be wiped off and cannot be diagnosed clinically; the spots are smooth, irregular in size and shape, hard, and occasionally fissured. Often associated with pipe smoking. Biopsy may show malignant or premalignant changes.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


(loo?ko-pla'ke-a) [ leuko- + Gr. plax, plate + -ia]
Enlarge picture
Formation of white spots or patches on the mucous membrane of the tongue or cheek. The spots are smooth, irregular in size and shape, hard, and occasionally fissured. The lesions may become malignant. Synonym: leukokoria; leukoplasia; smoker's tongue See: illustration

leukoplakia buccalis

Leukoplakia of the mucosa of the cheek.
Enlarge picture

oral hairy leukoplakia

Leukoplakia of the tongue. It is typically found in immunocompromised patients is a result of Epstein-Barr virus infection.

leukoplakia vulvae

Lichen sclerosis et atrophicus.
Medical Dictionary, © 2009 Farlex and Partners


A thickened white patch occurring on a mucous membrane, especially inside the mouth, on the lips or on the female genitalia. Leukoplakia is a response to long-term irritation and is a PRECANCEROUS condition that should never be ignored.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


White patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, no histologic connotation.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs.
Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
The potential malignant lesions of the oral region are associated with alcohol drinking, tobacco and betel nut are erythroplakia, leukoplakia, proliferative verrucousleukoplakia, etc (Table-1).
They found an increased expression of p16 in 64% of OLP patients as compared to that in only 28% of patients with oral leukoplakia. No differences were observed between samples from patients with OLP and those with nonspecific reactive inflammation.
Examination revealed two distinct lesions of leukoplakia on the right upper eyelid margin, extending onto the tarsal conjunctiva found on eye lid eversion and measuring 5 mm horizontally (Figure 1).
Known external risk factors are poor nutrition, alcohol abuse, tobacco exposure, erythroplakia, and leukoplakia [12].
The global prevalence of HPV was reported to be higher in oral potentially malignant disorders (OPMD) cases than in controls (OR: 3.98, 95% CI: 2.62-6.02), and among the different subgroups of OPMD, the prevalence was higher in the dysplasia (OR: 5.10, 95% CI: 2.03-12.80) and leukoplakia (OR: 4.03, 95% CI: 2.34-6.92) subgroups [36].
proposed COX-2 and Ki67 as biomarkers for the malignant transformation of oral leukoplakia. They revealed a higher COX-2 expression in OSCC samples compared to oral intraepithelial leukoplakia and oral hyperkeratosis, with a positive correlation between COX-2 levels and the severity of the lesions being observed.
A wide variety of oral lesions in HIV-infected pediatric patients are reported in the literature, such as: candidiasis (8,10-12), gingivitis (12-14), oral hairy leukoplakia (9,13),Kaposi's sarcoma (5,10,15), parotid enlargement (1,4,14,16), herpes simplex (1,2).
In South-East Asian countries like India, another etiological factor is the use of areca nut leading to the occurrence of oral submucous fibrosis (OSMF) which is an OPMD.[1] Other OPMDs include leukoplakia, erythroplakia, erosive lichen planus, discoid lupus erythematosus, and palatal lesions due to reverse smoking.[7] Most OSCCs are preceded by OPMDs.[8]