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Related to leukoplakia: leukoplakia vulvae


a disease marked by the development of white thickened patches on the mucous membranes of the cheeks (leukoplakia buccalis), gums, or tongue (leukoplakia lingualis); the patches sometimes form fissures and often become malignant. They may grow into larger patches or form ulcers. Those in the mouth may in time cause pain during swallowing of food or speaking. Leukoplakia affects mostly middle-aged to elderly men, often after prolonged irritation of the mouth from such varying factors as badly fitting dentures or immoderate use of tobacco.

Treatment is aimed at removing any possible cause of physical or chemical irritation; the patient should give up tobacco and possibly also alcohol and extremely hot food. Dental attention may be necessary if teeth are uneven or dentures do not fit properly. Surgical removal of the affected area is relatively simple and may be the best means of preventing further development of the condition.
oral hairy leukoplakia a white filiform to flat patch occurring on the tongue or, rarely, on the buccal mucosa, caused by infection with Epstein-Barr virus and associated with human immunodeficiency virus infection.
leukoplakia vul´vae the presence of hypertrophic grayish-white infiltrated patches on the vulvar mucosa; specific diagnosis is determined by biopsy.


A white patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, a clinical term without histologic connotation.
Synonym(s): smoker's patches
[leuko- + G. plax, plate]


/leu·ko·pla·kia/ (-pla´ke-ah)
1. a white patch on a mucous membrane that will not rub off.

atrophic leukoplakia  lichen sclerosus in females.
oral leukoplakia  white, thick patches on the oral mucosa due to hyperkeratosis of the epithelium, producing favorable conditions for development of epidermoid carcinoma; often occurring on the cheeks (l. bucca´lis), gums, or tongue (l. lingua´lis) .
oral hairy leukoplakia  a white filiform to flat patch on the tongue or the buccal mucosa, caused by infection with Epstein-Barr virus and associated with human immunodeficiency virus infection.
leukoplakia vul´vae 
1. lichen sclerosus in females.
2. any white-appearing lesion of the vulva.


(lo͞o′kə-plā′kē-ə) also


An abnormal condition characterized by white spots or patches on mucous membranes, especially of the mouth and vulva. Also called leukoplasia.


Etymology: Gk, leukos + plakos, plate
a precancerous, slowly developing change in a mucous membrane characterized by thickened, white, firmly attached patches that are slightly raised and sharply circumscribed. They may occur on the penis or vulva. Those appearing on the lips and buccal mucosa are associated with pipe smoking. Malignant potential is evaluated by microscopic study of biopsied tissue. Compare lichen planus. See also lichen sclerosis et atrophicus.
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leukoplakia (vulvar)

Chronic vulvar dystrophy, see there.  

The term leukoplakia continues to be widely used (incorrectly) in the working gynaecological parlance; the error lies in that the term leukoplakia merely refers to the macroscopic appearance of white patches in the postmenopausal vulva, which most commonly correspond to hyper- or parakeratosis and far less commonly to carcinoma in situ or Paget's disease. The portent of vulvar leukoplakia is thus in sharp contrast to oral leukoplakia, which is generally regarded as a pre-malignant lesion.


A potentially precancerous white patch or plaque on a mucosa characterized by epithelial hyperplasia and hyperkeratosis, often caused by chronic irritation; leukoplakia–LP affects the mucosa of oral cavity, upper respiratory tract, vulva, uterine cervix, renal pelvis, urinary bladder; in each site, the significance differs ENT Smoker's keratosis A white plaque or patch on the oral mucosa. See Hairy leukoplakia Ob/Gyn A white plaque or patch on the vaginal mucosa, seen without magnification or acetic acid, and often elevated from surrounding surfaces with a sharp border and Lugol's non-staining Histology Hyperkeratosis, possibly epithelial proliferation. See Speckled leukoplakia.


A white patch of oral mucous membrane that cannot be wiped off and cannot be diagnosed clinically; the spots are smooth, irregular in size and shape, hard, and occasionally fissured. Often associated with pipe smoking. Biopsy may show malignant or premalignant changes.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]


(loo?ko-pla'ke-a) [ leuko- + Gr. plax, plate + -ia]
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Formation of white spots or patches on the mucous membrane of the tongue or cheek. The spots are smooth, irregular in size and shape, hard, and occasionally fissured. The lesions may become malignant. Synonym: leukokoria; leukoplasia; smoker's tongue See: illustration

leukoplakia buccalis

Leukoplakia of the mucosa of the cheek.
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oral hairy leukoplakia

Leukoplakia of the tongue. It is typically found in immunocompromised patients is a result of Epstein-Barr virus infection.

leukoplakia vulvae

Lichen sclerosis et atrophicus.


A thickened white patch occurring on a mucous membrane, especially inside the mouth, on the lips or on the female genitalia. Leukoplakia is a response to long-term irritation and is a PRECANCEROUS condition that should never be ignored.

leukoplakia (lōō·kō·plaˑ·kē·),

n plaque like white lesion that develops in the oral mucosa. Typically a sign of bodily irritation in response to cigarette smoke or tobacco chewing. In 10% of cases, these lesions are considered precancerous.
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White patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, no histologic connotation.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]
References in periodicals archive ?
03 dysplasia Table 3--Distribution of subjects with exophytic-growing oral nodules (nonneoplastic proliferative disorder and benign mesenchymal tumors), leukoplakia and squamous cell carcinoma according to demographic characteristics.
6% identified leukoplakia as the next highest suspect lesion.
The University of Maryland study reported that 91 percent of dental hygienists correctly conducted examinations of the tongue for oral cancer detection, while only 16 percent correctly identified leukoplakia and erythroplakia as conditions associated with oral cancer.
49%), enlargement of Oral candidiasis and the parotid glands hairy leukoplakia were (13%), oral positive predictors candidiasis (11%), for progression of the hairy leukoplakia disease.
RCTs investigating the effectiveness of chemopreventive agents for patients with premalignant lesions, leukoplakia or erythroplakia were included.
Gutkha chewing and smoking were the habits associated with OSMF and leukoplakia, respectively.
HPV18 was detected in 5% (2/40) of cases with leukoplakia and HPV56 in 10% (4/40) of cases with lichen planus.
The present study shows various lesions presented as ulcers and membranous lesions, among them patients came with ulcers were 23 cases of aphthous ulcers, 8 cases of oral submucous fibrosis, 10 cases of malignant lesions, 2 cases of dental ulcers, pemphigus vulgaris, traumatic ulcers, leukoplakia and lichen planus respectively.
There is also an increased risk of oral leukoplakia (pre-cancer) and oral cancer; 75 percent of cases of oral cancer and lip cancer occur in smokers.
Out of 147 cases diagnosed as nonneoplastic lesion: 7 were fibroepithelial polyp, 69 were leukoplakia, 17 were erythroleukoplakia, 18 were verrucous leukoplakia, 3 were oral tuberculosis, 1 was pemphigus, and 32 were inflammatory lesions, however, 3 (2.
Under the supervision of the professional dental office staff, the UNH students were photographed performing a variety of dental procedures, including checking for caries, periodontal disease and leukoplakia, taking blood pressure, performing head and neck examinations and consulting with their patients.
It also has been shown to prevent and treat oral diseases, such as oral cancer, leukoplakia (patches on mucus membranes), and periodontal disease (International Journal of Preventive Medicine, 2015).