leukoencephalopathy


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leukoencephalopathy

 [loo″ko-en-sef″ah-lop´ah-the]
any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē),
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]
References in periodicals archive ?
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation.
The report provides comprehensive information on the therapeutics under development for Progressive Multifocal Leukoencephalopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Toxic leukoencephalopathy refers to progressive damage of the white matter of the brain, particularly myelin.
According to the database PubMed using the key words of "reversible posterior leukoencephalopathy syndrome and sunitinib", only 11 cases of RPLS due to sunitinib have been reported in the literature (Table 1) [3-8].
Though Alexander disease, Canavan disease, and Glutaric aciduria have been considered as differential diagnosis of megalencephalic leukoencephalopathy with subcortical cysts, [9] these conditions are quite unlikely to have such a mild clinical course.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Geriatr Psychol Neuropsychiatr Vieil 2014;12(2):183-192.
Presentation of reversible posterior leukoencephalopathy syndrome in patients on calcineurin inhibitors.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: from stroke to vessel wall physiology.
[ClickPress, Wed Oct 10 2018] Progressive multifocal leukoencephalopathy (PML) is a rare, fatal disease that causes continual damage to the white matter of the brain, at different locations.
Progressive multifocal leukoencephalopathy (PML) is a life-threatening disease of the central nervous system caused by JC polyoma virus (JCV).
Two days after admission, brain magnetic resonance imaging (MRI) indicated diffuse white matter damage characteristic of toxic leukoencephalopathy. The patient was transferred to a tertiary care facility.