leukoencephalopathy


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leukoencephalopathy

 [loo″ko-en-sef″ah-lop´ah-the]
any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē),
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]
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References in periodicals archive ?
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation.
Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
The report provides comprehensive information on the therapeutics under development for Progressive Multifocal Leukoencephalopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Newly released market study: Progressive Multifocal Leukoencephalopathy - Pipeline Review, H1 2016
Toxic leukoencephalopathy refers to progressive damage of the white matter of the brain, particularly myelin.
Heroin-induced toxic leukoencephalopathy
According to the database PubMed using the key words of "reversible posterior leukoencephalopathy syndrome and sunitinib", only 11 cases of RPLS due to sunitinib have been reported in the literature (Table 1) [3-8].
Reversible posterior leukoencephalopathy syndrome developing after restart of sunitinib therapy for metastatic renal cell carcinoma
Though Alexander disease, Canavan disease, and Glutaric aciduria have been considered as differential diagnosis of megalencephalic leukoencephalopathy with subcortical cysts, [9] these conditions are quite unlikely to have such a mild clinical course.
Unusual case of Van Der Knaap's Disease presenting at 2 years of age following head trauma
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Geriatr Psychol Neuropsychiatr Vieil 2014;12(2):183-192.
Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
Presentation of reversible posterior leukoencephalopathy syndrome in patients on calcineurin inhibitors.
POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME (PRES)--CASE REPORT & REVIEW OF LITERATURE
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: from stroke to vessel wall physiology.
A CADASIL Case Presenting with Progressive Bulbar Palsy Caused by Acute Simultaneous Multiple Subcortical Infarcts
Posterior reversible leukoencephalopathy syndrome in a pre-eclamptic woman.
A Case of Posterior Reversible Encephalopathy Syndrome Confused With Encephalitis/ Ensefalitle Karisan Bir Posterior Reversibl Ensefalopati Sendromu Olgusu
[ClickPress, Wed Oct 10 2018] Progressive multifocal leukoencephalopathy (PML) is a rare, fatal disease that causes continual damage to the white matter of the brain, at different locations.
Progressive Multifocal Leukoencephalopathy Treatment Market to Register High Revenue Growth at 2.8%
Progressive multifocal leukoencephalopathy (PML) is a life-threatening disease of the central nervous system caused by JC polyoma virus (JCV).
Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
Two days after admission, brain magnetic resonance imaging (MRI) indicated diffuse white matter damage characteristic of toxic leukoencephalopathy. The patient was transferred to a tertiary care facility.
Toxic Leukoencephalopathy Associated with Tianeptine Misuse--California, 2017

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