leukoencephalopathy


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leukoencephalopathy

 [loo″ko-en-sef″ah-lop´ah-the]
any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē),
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

/leu·ko·en·ceph·a·lop·a·thy/ (-en-sef″ah-lop´ah-the) any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.
progressive multifocal leukoencephalopathy  a form due to opportunistic infection of the central nervous system by the JC virus, with demyelination occurring usually in the cerebral hemispheres and rarely in the brain stem and cerebellum.

leukoencephalopathy

[lo̅o̅′kō·ən·sef′əlop′əthē]
Etymology: Gk, leukos, white + enkephalos, brain + pathos, disease
any of a group of diseases affecting the white matter of the brain, especially of the cerebral hemispheres, occurring as a rule in infants and children. The term leukodystrophy is used to denote such disorders resulting from a defect in the formation and the maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

any of a group of diseases affecting the white substance of the brain.
References in periodicals archive ?
The investigation turned up no additional cases of multifocal leukoencephalopathy beyond the three patients that had been reported previously, noted Biogen Idec and Elan Pharmaceuticals in written statements.
Food and Drug Administration approval months earlier for relapsing forms of multiple sclerosis (MS) was being suspended because of one confirmed case of progressive multifocal leukoencephalopathy (PML) in a patient who had died, and a second suspected case.
The companies are proposing updated product labeling to include anti-JC Virus antibody status as one potential factor to help stratify the risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, in the TYSABRI-treated population.
Two weeks later, he was found to have posterior leukoencephalopathy and a blood pressure of 220/140 mm Hg, the investigators said (Am.
PARIS -- Cytheris SA, a clinical-stage biopharmaceutical company focused on research and development of new therapies for immune modulation, today announced the publication of a case study report based on successful treatment of Progressive Multifocal Leukoencephalopathy (PML) with combination therapy consisting of two investigational agents, Cytheris' recombinant human interleukin-7 (CYT107) and CMX001, an investigational, oral broad-spectrum antiviral drug (Chimerix, Research Triangle Park, NC) in the Journal of Antimicrobial Chemotherapy.
Sales of the product have slowed after being linked with a potentially deadly brain infection known as progressive multifocal leukoencephalopathy, or PML.
SAN DIEGO, March 10, 2013 /PRNewswire-USNewswire/ -- The drug natalizumab is effective for treating multiple sclerosis (MS), but it increases the risk of a rare but potentially fatal brain infection called progressive multifocal leukoencephalopathy (PML).
Updated Incidence of Progressive Multifocal Leukoencephalopathy in Natalizumab-Treated Multiple Sclerosis Patients Stratified by Established Risk Factors (S41.
This welcome news comes after two European patients treated with Tysabri developed the potentially fatal brain infection progressive multifocal leukoencephalopathy (PML) earlier this year.
Food and Drug Administration allowed marketing of the first test to help determine the risk for a rare brain infection called progressive multifocal leukoencephalopathy (PML) in people using the drug Tysabri (natalizumab) to treat multiple sclerosis (MS) or Crohn's disease (CD).
patient has contracted progressive multifocal leukoencephalopathy, a brain infection that killed one of four other patients the company already knew about, Chief Executive Officer James Mullen told analysts and investors.