leukoencephalopathy


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leukoencephalopathy

 [loo″ko-en-sef″ah-lop´ah-the]
any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē),
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

/leu·ko·en·ceph·a·lop·a·thy/ (-en-sef″ah-lop´ah-the) any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.
progressive multifocal leukoencephalopathy  a form due to opportunistic infection of the central nervous system by the JC virus, with demyelination occurring usually in the cerebral hemispheres and rarely in the brain stem and cerebellum.

leukoencephalopathy

[lo̅o̅′kō·ən·sef′əlop′əthē]
Etymology: Gk, leukos, white + enkephalos, brain + pathos, disease
any of a group of diseases affecting the white matter of the brain, especially of the cerebral hemispheres, occurring as a rule in infants and children. The term leukodystrophy is used to denote such disorders resulting from a defect in the formation and the maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

any of a group of diseases affecting the white substance of the brain.
References in periodicals archive ?
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a disease which manifests as migraine headaches and transient ischaemic attacks (TIA) between the ages 40 and 50 years.
Unilateral reversible posterior leukoencephalopathy syndrome after coiling of an aneurysm.
Additionally, the report provides an overview of key players involved in therapeutic development for Progressive Multifocal Leukoencephalopathy and features dormant and discontinued projects.
Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate immunosuppressive conditions.
Toxic leukoencephalopathy refers to progressive damage of the white matter of the brain, particularly myelin.
PRES is characterized by reversible radiographic signs of posterior leukoencephalopathy in the presence of headache, altered level of consciousness, and seizures with or without visual disturbances [5].
According to the database PubMed using the key words of "reversible posterior leukoencephalopathy syndrome and sunitinib", only 11 cases of RPLS due to sunitinib have been reported in the literature (Table 1) [3-8].
Case reports also describe an uncommon demyelinating syndrome, delayed post-hypoxic leukoencephalopathy (DPHL), which develops several weeks or months after a cerebral anoxic insult.
Multifocal leukoencephalopathy associated with 5-fluorouracil and levamisole adjuvant therapy for colon cancer.
DISCUSSION: MLC is a rare neurodegenerative disorder characterized by infantile-onset megalencephaly, cerebral leukoencephalopathy, and delayed onset of slowly progressive neurologic dysfunction.
Hinchey et al (3) first described reversible posterior leukoencephalopathy syndrome (which later became known as PRES) in 1996.