leukoencephalopathy


Also found in: Dictionary, Wikipedia.

leukoencephalopathy

 [loo″ko-en-sef″ah-lop´ah-the]
any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē),
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

/leu·ko·en·ceph·a·lop·a·thy/ (-en-sef″ah-lop´ah-the) any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.
progressive multifocal leukoencephalopathy  a form due to opportunistic infection of the central nervous system by the JC virus, with demyelination occurring usually in the cerebral hemispheres and rarely in the brain stem and cerebellum.

leukoencephalopathy

[lo̅o̅′kō·ən·sef′əlop′əthē]
Etymology: Gk, leukos, white + enkephalos, brain + pathos, disease
any of a group of diseases affecting the white matter of the brain, especially of the cerebral hemispheres, occurring as a rule in infants and children. The term leukodystrophy is used to denote such disorders resulting from a defect in the formation and the maintenance of myelin in infants and children.

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leukoencephalopathy

any of a group of diseases affecting the white substance of the brain.
Mentioned in ?
References in periodicals archive ?
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a disease which manifests as migraine headaches and transient ischaemic attacks (TIA) between the ages 40 and 50 years.
Magnetic resonance spectroscopy and magnetic resonance spectroscopic imaging in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: A literature review
Unilateral reversible posterior leukoencephalopathy syndrome after coiling of an aneurysm.
Atypical presentation of posterior reversible encephalopathy syndrome: clinical and radiological characteristics in eclamptic patients
Additionally, the report provides an overview of key players involved in therapeutic development for Progressive Multifocal Leukoencephalopathy and features dormant and discontinued projects.
Newly released market study: Progressive Multifocal Leukoencephalopathy - Pipeline Review, H1 2016
Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate immunosuppressive conditions.
JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
The role of tumor lysis in reversible posterior leukoencephalopathy syndrome.
Reversible Posterior Leukoencephalopathy Syndrome Sometimes Could be Irreversible: A Case Following Tumor Lysis Syndrome in Childhood Burkitt's Lymphoma
Toxic leukoencephalopathy refers to progressive damage of the white matter of the brain, particularly myelin.
Heroin-induced toxic leukoencephalopathy
PRES is characterized by reversible radiographic signs of posterior leukoencephalopathy in the presence of headache, altered level of consciousness, and seizures with or without visual disturbances [5].
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome
According to the database PubMed using the key words of "reversible posterior leukoencephalopathy syndrome and sunitinib", only 11 cases of RPLS due to sunitinib have been reported in the literature (Table 1) [3-8].
Reversible posterior leukoencephalopathy syndrome developing after restart of sunitinib therapy for metastatic renal cell carcinoma
Case reports also describe an uncommon demyelinating syndrome, delayed post-hypoxic leukoencephalopathy (DPHL), which develops several weeks or months after a cerebral anoxic insult.
Malignant catatonia and aphasia follow multiple-drug overdose
Multifocal leukoencephalopathy associated with 5-fluorouracil and levamisole adjuvant therapy for colon cancer.
Encefalopatia inducida por 5-fluorouracilo un mismo agente, dos entidades diferentes
DISCUSSION: MLC is a rare neurodegenerative disorder characterized by infantile-onset megalencephaly, cerebral leukoencephalopathy, and delayed onset of slowly progressive neurologic dysfunction.
Unusual case of Van Der Knaap's Disease presenting at 2 years of age following head trauma
Hinchey et al (3) first described reversible posterior leukoencephalopathy syndrome (which later became known as PRES) in 1996.
The case

Medical browser ?
Full browser ?