leukocytoclastic vasculitis


Also found in: Acronyms.

leu·ko·cy·to·clas·tic vas·cu·li·tis

cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis.
[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]

allergic vasculitis

A form of nonthrombocytopenic purpura due to a hypersensitivity vasculitis associated with urticaria, erythema, arthritis, gastrointestinal symptoms and renal involvement.

leukocytoclastic vasculitis

Cutaneous necrotizing vasculitis A form of vasculitis with fragmentation of neutrophil nuclei, immune complex deposition–direct immunofluorescence demonstrates IgG, IgM and complement deposition, that elicits neutrophilic 'suicide' and deposition of abundant nuclear 'dust', necrotic debris and fibrin, most common in small post-capillary venules; the condition may be local–eg, cutaneous or systemic. See Vasculitis.

leu·ko·cy·to·clas·tic vas·cu·li·tis

(lū'kō-sī-tō-klas'tik vas'kyū-lī'tis)
Cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red blood cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis
[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]
References in periodicals archive ?
However, the skin biopsy revealed leukocytoclastic vasculitis and negative staining for Congo red and [kappa]-light chain, without IgA deposition.
We report the case of a 30-year-old man with visceral leishmaniasis (kala-azar) and leukocytoclastic vasculitis. The patient improved symptomatically following treatment with amphotericin B.
In conclusion, our patient presented with a clinical picture of leukocytoclastic vasculitis and necrotizing pneumonia, and a diagnosis of hydatid cyst disease of the lung was made.
Leukocytoclastic vasculitis with perivascular localization and polymorphonuclear leukocytes' accumulation in the dermis was detected in the biopsy specimen taken from the active lesion (Figure 1c).
HSP, also known as anaphylactoid purpura and immunoglobulin A (IgA) vasculitis, is a small-vessel leukocytoclastic vasculitis characterized by the perivascular deposition of IgAl-based immune complexes in the walls of arterioles and postcapillary venules.
reported hypergammaglobulinemia in 50% of pSS patients with cutaneous purpura not associated with cryoglobulinemia, and the main histologic diagnosis of cutaneous vasculitis was leukocytoclastic vasculitis.[4] Ramos-Casals et al .[16] also found that pSS patients with low C4 level had a higher incidence of cutaneous vasculitis.
Microscopic evaluation reveals leukocytoclastic vasculitis. Perinuclear ANCA is more often positive than c-ANCA.
The differential diagnosis for venous stasis dermatitis includes cellulitis (which rarely presents bilaterally), deep vein thrombosis, asteatotic dermatitis, erysipelas (more superficial cellulitis that results in elevated, shiny plaques), pyomyositis, necrotizing fasciitis, leukocytoclastic vasculitis, and allergic contact dermatitis.
Histological findings of papillary dermal edema, karyorrhexis, and the presence of neutrophils within the inflammatory infiltrate without evidence of leukocytoclastic vasculitis supported Sweet's Syndrome.
Leukocytoclastic vasculitis and polyarteritis nodosa are most frequently associated with MDS [12].
Biopsy of the rash from his calf was positive for leukocytoclastic vasculitis. Autoimmune workup was negative except for elevated C-reactive protein (CRP).