leukocyte esterase test


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leu·ko·cyte es·ter·ase test

(LET) (lū'kō-sīt es'tĕr-ās test)
A chemical assay to determine the presence of lysed or intact white blood cells in urine, performed with a dipstick as part of routine urinalysis; serves as an adjunct to microscopic examination of urinary sediment, and used to screen asymptomatic people for urinary tract infection, especially chlamydial urethritis.
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A positive leukocyte esterase test results from the presence of white blood cells, either as whole cells or as lysed cells.
The presence of white cells might result in a positive leukocyte esterase test; however, the test is fairly insensitive.
The sensitivity of the leukocyte esterase test compared with the C trachomatis culture was 71.4%, and compared with the N gonorrhoeae culture was 89.6%.
These samples were deemed negative based on the leukocyte esterase test and/or nitrite test, but a culture revealed significant bacteriuria.

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