In our model, CALM/AF10 expression occurred in hematopoietic progenitors with restricted capacity of differentiation and our results suggest that CALM/AF10 may not be leukemogenic
in this cell compartment.
Ptpn11 allele causes defective erythropoiesis in mice," PLoS One, vol.
mutations alone, such as FLT3, NPM1, CEBPA, and DNMT3A, are not sufficient to explain diverse clinical AML subtypes; epigenetic alterations are abundant and common and might explain the biology behind various AML groups.
Assessing the potential leukemogenic
effects of 50 Hz magnetic fields and their harmonics using an animal leukemia model.
Gutierrez et al., "ZRF1 controls the retinoic acid pathway and regulates leukemogenic
potential in acute myeloid leukemia," Oncogene, vol.
risk of Hydroxyurea is extrapolated from its reported risk in myeloproliferative disorders.
For example, benzene is a classical hemopoietic xenobiotic, for which toxic and leukemogenic
effects in humans and animal species are well-documented in the literature [1,2].
These findings indicate that perturbation of these genes through DNA methylation is likely to be necessary, though probably not sufficient for leukemogenic
Dameshek hesitated to use a potentially dangerous radioactive material in an individual with a relatively long lifespan (2) and questioned whether the acute leukemic states that have occurred in some cases are due to the potentially leukemogenic
drug P32 or are associated with the natural history of polycythemia.
Garcia-Orti et al., "SETBP1 overexpression is a novel leukemogenic
mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia," Blood, vol.
In addition, the combination of genomics and xenotransplant models has indicated unsuspected genetic diversity within multiple leukemogenic
subclones, consistent with the model of multiclonal evolution [17-19], outlining the importance of seeking marks from the earliest hematopoietic events in ALL and investigating the competence of stem and progenitor cells to efficiently develop and replenish the immune system of these hematological patients.
Defective DNA-mismatch repair: a potential mediator of leukemogenic
susceptibility in therapy-related myelodysplasia and leukemia.