leukemogenesis


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leukemogenesis

 [loo-ke″mo-jen´ĕ-sis]
the induction or development of leukemia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

leu·ke·mo·gen·e·sis

(lū-kē'mō-jen'ĕ-sis),
The causation (or induction), development, and progression of a leukemic disease.
[leukemia + G. genesis, production]
Farlex Partner Medical Dictionary © Farlex 2012

leukemogenesis

A process in which successive transformational events enhance the ability of hematopoietic progenitor cells to proliferate, differentiate, and survive. See Autonomous proliferation.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

leu·ke·mo·gen·e·sis

(lū-kē'mō-jen'ĕ-sis)
The causation (or induction), development, and progression of a leukemic disease.
Synonym(s): leukaemogenesis.
[leukemia + G. genesis, production]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The genes to be analyzed were selected because of their attributes as key regulators during different stages of hematopoiesis and leukemogenesis, as well as their more or less distinct organ specificity: NCAM1 and RUNX1 as representatives of genes with functions (hematopoiesis, osteogenesis, cell adhesion) on many cell types (hematopoietic cells, neurons, muscles) of various differentiated tissues (embryonic cells, differentiated cells), GATA1 and SPI1 having more circumscribed compartments and cell types (erythropoiesis/megakaryopoiesis, myelopoiesis, and lymphopoiesis).
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.
Thus, it is more likely that FAMLF-CS is associated with hematopoietic cell differentiation rather than leukemogenesis.
In our study, expression of the PML/RAR[alpha] fusion gene was decreased after patients achieved complete remission following retinoid acid induction, and miR-146a expression decreased simultaneously, indicating that miR146a was regulated by PML/RAR[alpha] in the leukemogenesis of APL.
OBJECTIVES: We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by auioxidation, to investigate the toxicity of benzene leading to leukemogenesis.
The main driving force of leukemogenesis in CML is reciprocal translocation between chromosomes 9 and 22, which produces a fusion protein (BCR-ABL) having constitutive tyrosine kinase activity, and, in turn, induces cell growth (35).
Kenneth Dorshkind, the researchers found that the two genes sensitise lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.
There is also material on the mechanisms by which retroviral insertion into hematopoietic stem cells results in leukemogenesis. Papers from the conference are grouped in sections on malignant and early hematopoiesis, mobilization, gene expression in stem cells, plasticity, regulators, clonality, and self-renewal.
Disease-specific RNA is often expressed in leukemia cells as a result of chromosome translocations that join two gene coding regions, leading to expression of an in-frame chimeric mRNA product that participates in leukemogenesis (1).
For instance, preleukemic DNMT3Amut HSCs which can initiate clonal expansion as the first step in leukemogenesis and regenerate the entire hematopoietic hierarchy were found to survive and expand in the bone marrow remission after chemotherapy [54].
Results: We described clonal evolution and how it changes our view on leukemogenesis, treatment responses, and disease relapse.