The genes to be analyzed were selected because of their attributes as key regulators during different stages of hematopoiesis and leukemogenesis
, as well as their more or less distinct organ specificity: NCAM1 and RUNX1 as representatives of genes with functions (hematopoiesis, osteogenesis, cell adhesion) on many cell types (hematopoietic cells, neurons, muscles) of various differentiated tissues (embryonic cells, differentiated cells), GATA1 and SPI1 having more circumscribed compartments and cell types (erythropoiesis/megakaryopoiesis, myelopoiesis, and lymphopoiesis).
A remote GATA2 hematopoietic enhancer drives leukemogenesis
in inv(3)(q21;q26) by activating EVI1 expression.
Thus, it is more likely that FAMLF-CS is associated with hematopoietic cell differentiation rather than leukemogenesis
In our study, expression of the PML/RAR[alpha] fusion gene was decreased after patients achieved complete remission following retinoid acid induction, and miR-146a expression decreased simultaneously, indicating that miR146a was regulated by PML/RAR[alpha] in the leukemogenesis
Immune system disorders have increased our understanding of leukemogenesis
OBJECTIVES: We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by auioxidation, to investigate the toxicity of benzene leading to leukemogenesis
The main driving force of leukemogenesis
in CML is reciprocal translocation between chromosomes 9 and 22, which produces a fusion protein (BCR-ABL) having constitutive tyrosine kinase activity, and, in turn, induces cell growth (35).
Kenneth Dorshkind, the researchers found that the two genes sensitise lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis
There is also material on the mechanisms by which retroviral insertion into hematopoietic stem cells results in leukemogenesis
. Papers from the conference are grouped in sections on malignant and early hematopoiesis, mobilization, gene expression in stem cells, plasticity, regulators, clonality, and self-renewal.
Disease-specific RNA is often expressed in leukemia cells as a result of chromosome translocations that join two gene coding regions, leading to expression of an in-frame chimeric mRNA product that participates in leukemogenesis
For instance, preleukemic DNMT3Amut HSCs which can initiate clonal expansion as the first step in leukemogenesis
and regenerate the entire hematopoietic hierarchy were found to survive and expand in the bone marrow remission after chemotherapy .
Results: We described clonal evolution and how it changes our view on leukemogenesis
, treatment responses, and disease relapse.