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hyperplasia of reticuloendothelial tissue.
leukemic reticuloendotheliosis hairy cell leukemia.
See hairy-cell leukemia.
The ‘classic’ or Japanese form—which comprises most cases of HCL—responds better to therapy than the non-classic or variant form
Lab Increased acid phosphatase, especially isoenzyme 5—increased in bone metastases and in Gaucher’s disease
Management First-line therapy: purine analogues 2’-deoxycoformycin (pentostatin) and 2-chlorodeoxyadenosine (cladribine)
Cause of death Infections, gram-negative bacteria, atypical mycobacteria, fungi
a superseded term for neoplasia of hemopoietic precursors. See also blast form of erythremic myelosis.
a group of diseases of poultry caused by the REV group of retroviruses, and includes a chronic neoplastic disease of turkeys and chickens, a runting disease in chickens accidentally injected with the virus, and possibly an acute reticulum cell neoplasia. The chronic neoplasia is manifested by nodular tumors in visceral organs.
leukemia marked by splenomegaly and by an abundance of large, mononuclear abnormal cells with numerous, irregular cytoplasmic projections that give them a flagellated or hairy appearance in the bone marrow, spleen, liver and peripheral blood; called also hairy-cell leukemia.