Tel Aviv University researchers, led by Michael Milyavsky, discuss their unique genetically encoded sensor and its ability to identify, isolate and characterize leukemic
stem cells in a study published in January.
We show that leukemic
cells and colon cancer cells grow in hPL equally well to slightly better than in FCS.
Genotyping distribution of BCL2 (rs2279115;-938 C>A) in leukemic
and healthy subjects Genotype No.
After removing the medium from plates, MSCs were adherent and MOLT-4 cells were suspended and in the medium just containing MOLT-4 cells, total RNA from leukemic
cells was extracted using RNX-Plus solution kit (Sinaclon, Tehran, Iran).
The course of disease experienced by this patient suggested that GIT involvement with leukemia might parallel leukemic
disease activity, as acceleration of the patient's WBC coincided with a worsening of his symptoms.
The bis-aminophosphonate B-6 (meso form) showed negligible cytostatic activity in all of the screened leukemic
variants ([IC.sub.50] > 100).
Peripheral smears, bone marrow aspirate, H&E and IHC staining show two distinct populations of leukemic
In my case, the leukemic
cells had lodged in and overwhelmed my spleen.
This also involved the left C6 to T1 nerve roots and extended into the supraclavicular and retroclavicular segment of the left brachial plexus over approximately 6.8 cm in length, most consistent with leukemic
As described for MDS, in AML, MSC-derived endothelial cells are significantly increased, especially in cases with rapidly proliferating disease, further suggesting MSCs derived cell implication in leukemic
In a previous study, transformation of retrovirus driver leukemia cells with constitutively active (CA) STAT5 signaling was employed to achieve second hit and leukemic
transformation ability .
Following this, immunohistochemistry was done which showed T cells positive for CD3/CD45RO with the histiocytes immunoreactive for CD68 in upper dermis suggestive of leprosy (Figures 5 and 6) and lower dermis with B-cells immunoreactive for CD20/CD5/CD23 suggestive of leukemic
infiltrate (Figures 7 and 8).