leukapheresis


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leukapheresis

 [loo″kah-fĕ-re´sis]
the selective removal of leukocytes from withdrawn blood, which is then retransfused into the donor.

leuk·a·phe·re·sis

(lūk'ă-fĕ-rē'sis),
A procedure, analogous to plasmapheresis, in which leukocytes are removed from the withdrawn blood and the remainder of the blood is retransfused into the donor.
[leuko- + G. aphairesis, a withdrawal]

leukapheresis

Therapeutics The removal of blood to collect specific blood cells; plasma is returned to the body. See Apheresis Transfusion medicine The separation of leukocytes from whole blood with/without platelets with continuous or intermittent return of the RBCs and platelet- and leukocyte-poor plasma to a donor. See Cytapheresis, Hemapheresis, Plateletpheresis.
Leukapheresis types  
'Harvesting' leukapheresis WBCs are donated from healthy subjects to immunocompromised and leukopenic Pts, which may be effective in short-term therapy of acute infections; long-term, Pts become either immunized against the donor antigens or infected with pathogens; 1010 granulocytes are needed for adequate 'coverage' against infections; to maximize the harvest, the donor receives corticosteroids
Reduction leukapheresis WBCs that compromise normal circulation are removed to temporarily relieve Sx of hyperleukemia–> 100 x 109/L; in a typical procedure, ± 6 liters of whole blood are processed to remove 5-10 x 109 WBCs

leuk·a·phe·re·sis

(lū'kă-fĕr-ē'sis)
A procedure, analogous to plasmapheresis, in which leukocytes are removed from the withdrawn blood and the remainder of the blood is retransfused into the donor.
Synonym(s): leucapheresis.
[leuko- + G. aphairesis, a withdrawal]
References in periodicals archive ?
Patients eligible for treatment will be those (1) who have recovered from surgery such that they are about to begin concurrent chemotherapy and radiation therapy (CT/RT), (2) for whom an autologous tumor cell line has been established, (3) have a Karnofsky Performance Status of > 70 and (4) have undergone successful leukapheresis from which peripheral blood mononuclear cells (PBMC) were obtained that can be used to generate dendritic cells (DC).
The effects of gender, age, type of diagnosis, weight, blood group, infused CD34+ dosage, period between diagnosis-transplant, preservation time of harvest product, amount of leukapheresis, conditioning regime, a number of previous chemotherapy cycle, pre-transplant radiotherapy, stage of disease during diagnosis, disease status at transplant, marrow infiltration, the number of plasma cells in bone marrow and post-transplant infection on neutrophil and platelet engraftment time were summarized in Table 4.
The X-BACS purifies and/or activates cells of interest from blood, bone marrow or leukapheresis in a semi-automated "closed system" process with precision and speed, concluded the company.
Peripheral blood mononuclear cells (PBMC) were obtained by a leukapheresis procedure from four advanced (stage IV) MM patients previously treated using a reported TAPCells vaccination protocol [19].
Patent and Trademark Office issued a patent to Cesca Therapeutics for a method ogf separating rare, therapeutically critical target cells from blood, bone marrow, leukapheresis product, and other cell sources, while maintaining the viability of the cells under asceptic conditions.
The leukapheresis team in the department of haematology at UHW successfully obtained cells of a high enough quality from the patient to enable the company - TC BioPharm - to manufacture ImmuniCell for a full course of treatment.
Leukapheresis may be considered in the first trimester to delay chemotherapy.
Patients required multiple leukapheresis procedures to provide more than 2 x [10.sup.6]/kg of [CD34.sup.+] cells per cycle to support several chemotherapy cycles.
Given her clinical deterioration from leukemia, in her final days she received her first treatment of CMML with hydroxyurea, then underwent leukapheresis, and received one dose of chemotherapy with decitabine one day prior to expiration.
Cellular therapy for human adult use usually means that autologous nucleated cells are harvested via either bone marrow (BM) aspiration or peripheral blood (PB) stem cell collection through leukapheresis or via liposuction [11].
Greaves et al., "Age-related disease association of endogenous [gamma]-H2AX foci in mononuclear cells derived from leukapheresis," PLoS One, vol.