leukaemias


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leukaemias

A group of blood disorders in which white blood cells reproduce in a disorganized and uncontrolled way and progressively displace the normal constituents of the blood. The leukaemias are a form of cancer (neoplasia) and unless effectively treated are usually fatal. Death occurs from a shortage of red blood cells (ANAEMIA), or from severe bleeding or from infection. The different types of leukaemia arise from different white cell types and have different outlooks. In most cases the cause is unknown but there are definite associations with radiation, with certain viruses, with some anticancer drugs and with some industrial chemicals such as benzene. Treatment is, at present, primarily by chemotherapy. Removal of the spleen may help. Blood transfusions and antibiotics are commonly required. Other treatments include RADIOTHERAPY, white cell transfusions, bone marrow transfusion after total body radiation, bone marrow removal, treatment to destroy malignant cells and its replacement. Some of these methods are still experimental.
References in periodicals archive ?
Diagnosing a cat with leukaemia virus can be challenging because the signs associated with the disease can be so varied.
We are seeing an increase in the incidence of leukaemia virus within the area in recent months.
Prof Eric So, who led the King's College London team, said: "These results are extremely exciting and represent a critical step forward in the search for more effective treatments for this devastating form of leukaemia.
But it is still rare, with just one in 10 leukaemia patients being kids - the equivalent of 500 diagnoses a year.
While childhood leukaemia could be initiated by DNA alterations in the unborn child, it is thought that leukaemia would only develop if there was another secondary trigger.
The team of specialists at the pounds 3million Paul O'Gorman Leukaemia Research Centre are involved in ground-breaking work that could mean wiping out the killer disease.
Leukaemia Research partially funded the new centre at Gartnavel Hospital, which opens officially on Thursday.
Reflecting a greater understanding of disease biology, the enthusiastic pursuit of Flt-3 inhibition in the development of novel acute myeloid leukaemia treatment has resulted in already crowded pipeline, with four products challenging for first-to-market status: Cephalons CEP-701, Novartis PKC-412, Millenniums MLN518 and Pfizers SU11248.
Identify the areas of unmet need and clinical controversy in acute leukaemia treatment.
PharmaMar's clinical portfolio currently includes Yondelis(TM) in phase II clinical trials (co-developed with Johnson & Johnson Pharmaceutical Research & Development), designated Orphan Drug for STS by the EMEA in 2001 and Orphan Drug for ovarian cancer in 2003; Aplidin(R), in phase II, designated Orphan Drug for acute lymphoblastic leukaemia in 2003; Kahalalide F in phase II and ES-285 in phase I clinical trials.
for the treatment of adult and pediatric acute lymphoblastic leukaemia and acute myeloid leukaemia.