leukaemias


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leukaemias

A group of blood disorders in which white blood cells reproduce in a disorganized and uncontrolled way and progressively displace the normal constituents of the blood. The leukaemias are a form of cancer (neoplasia) and unless effectively treated are usually fatal. Death occurs from a shortage of red blood cells (ANAEMIA), or from severe bleeding or from infection. The different types of leukaemia arise from different white cell types and have different outlooks. In most cases the cause is unknown but there are definite associations with radiation, with certain viruses, with some anticancer drugs and with some industrial chemicals such as benzene. Treatment is, at present, primarily by chemotherapy. Removal of the spleen may help. Blood transfusions and antibiotics are commonly required. Other treatments include RADIOTHERAPY, white cell transfusions, bone marrow transfusion after total body radiation, bone marrow removal, treatment to destroy malignant cells and its replacement. Some of these methods are still experimental.
References in periodicals archive ?
A total of 500 cells of WBC were counted and blasts cells over 20% are regarded as acute leukaemias.
Most of acute leukaemias can be classified as myeloid, B lymphoid and T lymphoid based on different antigenic expression of the blast cells.
It is responsible for up to 80% of acute leukaemias in adults with slight male preponderance.
The research was supported by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, Leukaemia and Lymphoma Research, the Leukemia and Lymphoma Society, Microsoft Research and the Wellcome Trust.
Acute leukaemias are malignant disorders which are rapidly fatal if left untreated but they are curable with appropriate treatment.
Occasionally we see a household with several cats who have all contracted feline leukaemia virus.
Only 50% of children diagnosed with MLL leukaemia survive longer than two years after receiving standard therapy.
Dr Cooke explained that previous research has shown kids who develop leukaemia tend to undergo changes to their DNA while in the womb.
WORLD-LEADING scientists at a new research centre in Scotland will have a cure for a key form of leukaemia within 10 years.
This approach is more likely to address the heterogeneity of acute leukaemia and will contribute to the increasing trend of risk-stratified treatment approaches.
PharmaMar's clinical portfolio currently includes Yondelis(TM) in phase II clinical trials (co-developed with Johnson & Johnson Pharmaceutical Research & Development), designated Orphan Drug for STS by the EMEA in 2001 and Orphan Drug for ovarian cancer in 2003; Aplidin(R), in phase II, designated Orphan Drug for acute lymphoblastic leukaemia in 2003; Kahalalide F in phase II and ES-285 in phase I clinical trials.
If approved by the FDA, clofarabine would be the first drug to be labeled for pediatric leukaemia exclusively in more than a decade.