Leucovorin rescue was discontinued as MTX levels were now 0.02 [micro]mol/L.
High dose methotrexate with
leucovorin rescue. Rationale and spectrum of antitumor activity.
After completion of MTX infusion for 6–8 h, leucovorin rescue (12 mg, q6h) is started until the serum concentration of MTX falls to 0.05 [micro]mol/L.
With sufficient leucovorin rescue, none of the 11 patients experienced a potentially pathogenic complication and did not require invasive treatment, and all proceeded to the next cycle of chemotherapy.{Table 4}
HD-MTX with leucovorin rescue is used to treat osteosarcoma (8-12 jers [m.sup.2]) and ALL ([less than or equal to]8 g/[m.sup.2]).
Carboxypeptidase-G2, thymidine and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
He received 4 cycles of high-dose methotrexate (HDMTX) [3] with
leucovorin rescue and 2 cycles of cisplatin and doxorubicin, which he tolerated well.
She underwent
leucovorin rescue as the thrombocytopenia was felt to be due to the methotrexate.
Treatment with intravenous HD-MTX and calcium
leucovorin rescue was begun.
The incidence of toxicity has decreased as a result of plasma MTX concentration monitoring and appropriate
leucovorin rescue, combined with adequate hydration and urine alkalinization.
The pediatric ALL community remains divided concerning the use of either "industrial" MTX doses with
leucovorin rescue [Berlin-Frankfurt-Munster Cooperative Group (BFM) (15), United Kingdom ALL Cooperative Group (UKALL) (1), and Nordic (10) studies] or repeated, escalating low doses of systemic MTX administered with absolutely no
leucovorin rescue, the so-called Capizzi methotrexate (5, 16), which also has apparent clinical efficacy (17, 18).
Several of these cancers are treated with high-dose methotrexate (HDMTX) regimens (i.e., MTX dose [greater than or equal to]1 gm/[m.sup.2]) followed by
leucovorin rescue (1-3).