leucovorin rescue

Oncology A strategy–administration of a formulation of vitamin B for preventing 'collateral damage' to normal cells when using MTX, an antimetabolite, to treat lymphomas and other malignancies, which may cause BM suppression and GI Sx. See Methotrexate.

References in periodicals archive ?

Leucovorin rescue was discontinued as MTX levels were now 0.02 [micro]mol/L.

A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity

High dose methotrexate with leucovorin rescue. Rationale and spectrum of antitumor activity.

Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report

After completion of MTX infusion for 6–8 h, leucovorin rescue (12 mg, q6h) is started until the serum concentration of MTX falls to 0.05 [micro]mol/L.

With sufficient leucovorin rescue, none of the 11 patients experienced a potentially pathogenic complication and did not require invasive treatment, and all proceeded to the next cycle of chemotherapy.{Table 4}

Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients

HD-MTX with leucovorin rescue is used to treat osteosarcoma (8-12 jers [m.sup.2]) and ALL ([less than or equal to]8 g/[m.sup.2]).

Carboxypeptidase-G2, thymidine and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.

Treatment of intrathecal methotrexate overdose with folinic acid rescue and lumbar cerebrospinal fluid exchange: a report of two cases / Yuksek doz intratekal metotreksat' in folinik asit ve beyin omurilik sivsi degisimi ile tedavisi: iki olgu sunumu

He received 4 cycles of high-dose methotrexate (HDMTX) [3] with leucovorin rescue and 2 cycles of cisplatin and doxorubicin, which he tolerated well.

Difficulty measuring methotrexate in a patient with high-dose methotrexate-induced nephrotoxicity

She underwent leucovorin rescue as the thrombocytopenia was felt to be due to the methotrexate.

Successful pregnancy following conservative surgical therapy of an invasive molar gestation

Treatment with intravenous HD-MTX and calcium leucovorin rescue was begun.

High-dose methotrexate and primary central nervous system lymphoma

The incidence of toxicity has decreased as a result of plasma MTX concentration monitoring and appropriate leucovorin rescue, combined with adequate hydration and urine alkalinization.

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

The pediatric ALL community remains divided concerning the use of either "industrial" MTX doses with leucovorin rescue [Berlin-Frankfurt-Munster Cooperative Group (BFM) (15), United Kingdom ALL Cooperative Group (UKALL) (1), and Nordic (10) studies] or repeated, escalating low doses of systemic MTX administered with absolutely no leucovorin rescue, the so-called Capizzi methotrexate (5, 16), which also has apparent clinical efficacy (17, 18).

Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited

Several of these cancers are treated with high-dose methotrexate (HDMTX) regimens (i.e., MTX dose [greater than or equal to]1 gm/[m.sup.2]) followed by leucovorin rescue (1-3).

Dihydrofolate reductase enzyme inhibition assay for plasma methotrexate determination using a 96-well microplate reader

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