leucovorin rescue

leucovorin rescue

Oncology A strategy–administration of a formulation of vitamin B for preventing 'collateral damage' to normal cells when using MTX, an antimetabolite, to treat lymphomas and other malignancies, which may cause BM suppression and GI Sx. See Methotrexate.
References in periodicals archive ?
Leucovorin rescue was discontinued as MTX levels were now 0.02 [micro]mol/L.
High dose methotrexate with leucovorin rescue. Rationale and spectrum of antitumor activity.
After completion of MTX infusion for 6–8 h, leucovorin rescue (12 mg, q6h) is started until the serum concentration of MTX falls to 0.05 [micro]mol/L.
With sufficient leucovorin rescue, none of the 11 patients experienced a potentially pathogenic complication and did not require invasive treatment, and all proceeded to the next cycle of chemotherapy.{Table 4}
HD-MTX with leucovorin rescue is used to treat osteosarcoma (8-12 jers [m.sup.2]) and ALL ([less than or equal to]8 g/[m.sup.2]).
Carboxypeptidase-G2, thymidine and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
He received 4 cycles of high-dose methotrexate (HDMTX) [3] with leucovorin rescue and 2 cycles of cisplatin and doxorubicin, which he tolerated well.
She underwent leucovorin rescue as the thrombocytopenia was felt to be due to the methotrexate.
Treatment with intravenous HD-MTX and calcium leucovorin rescue was begun.
The incidence of toxicity has decreased as a result of plasma MTX concentration monitoring and appropriate leucovorin rescue, combined with adequate hydration and urine alkalinization.
The pediatric ALL community remains divided concerning the use of either "industrial" MTX doses with leucovorin rescue [Berlin-Frankfurt-Munster Cooperative Group (BFM) (15), United Kingdom ALL Cooperative Group (UKALL) (1), and Nordic (10) studies] or repeated, escalating low doses of systemic MTX administered with absolutely no leucovorin rescue, the so-called Capizzi methotrexate (5, 16), which also has apparent clinical efficacy (17, 18).
Several of these cancers are treated with high-dose methotrexate (HDMTX) regimens (i.e., MTX dose [greater than or equal to]1 gm/[m.sup.2]) followed by leucovorin rescue (1-3).