leucovorin


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leucovorin

 [loo″ko-vor´in]
leucovorin calcium the calcium salt of folinic acid, used as an antidote for folic acid antagonists, e.g., methotrexate, when there is need to reverse the toxic effects of the latter, in the treatment of megaloblastic anemias due to folic acid deficiency, and as an adjunct in the palliative treatment of colorectal carcinoma; administered orally, intramuscularly, or intravenously.

fo·lin·ic ac·id

(fō-lin'ik as'id),
1. The active form of folic acid that acts as a formyl group carrier in transformylation reactions; the calcium salt, leucovorin calcium, has therapeutic use.
2. The term is occasionally applied to other folates.

leucovorin

/leu·co·vo·rin/ (-vor´in) folinic acid; the calcium salt is used as an antidote for folic acid antagonists, e.g., methotrexate, and in the treatment of megaloblastic anemias due to folic acid deficiency and colorectal carcinoma.

leucovorin

(lo͞o′kə-vôr′ĭn, lo͞o-kŏv′ər-ĭn)
n.
A form of folic acid that is used to counteract the toxic effects of folic acid antagonists such as methotrexate and is also given as an adjuvant to increase the effectiveness of certain chemotherapy drugs, such as fluorouracil. It is usually given in the form of its calcium salt.

leucovorin

leucovorin

References in periodicals archive ?
Simultaneously, the frequency and dose of leucovorin rescue were increased with continuous hydration and alkalinization to maintain urine pH at 7–9 to eliminate MTX as quickly as possible.
The studies for the determination of leucovorin were carried out with many analytical techniques in the past.
2] administration in combination with thymidine and leucovorin is highly effective, decreasing plasma MTX concentration by 95%-99% within 15 min in patients with HDMTX-induced nephrotoxicity (4, 5).
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.
Calcium leucovorin, sodium bicarbonate, and hydration were given to her as an outpatient.
We conclude from our experience in 123 heavily pretreated colorectal cancer patients that the combination of oxaliplatin with weekly bolus-only 5-FU and leucovorin has only modest therapeutic benefit.
Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group phase II study.
We present a 57-year-old black female with Dukes C colon carcinoma who, despite receiving a right hemicolectomy at the time of initial diagnosis, developed neutropenic enterocolitis after tr eatment with 5-fluorouracil and leucovorin.
M2 EQUITYBITES-October 23, 2015-PharmaEngine awarded US FDA's approval for ONIVYDE in combination with fluorouracil and leucovorin for metastatic pancreatic cancer
M2 PHARMA-October 23, 2015-United States FDA approves Merrimack's ONIVYDE in combination with fluorouracil and leucovorin