leucovorin


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leucovorin

 [loo″ko-vor´in]
leucovorin calcium the calcium salt of folinic acid, used as an antidote for folic acid antagonists, e.g., methotrexate, when there is need to reverse the toxic effects of the latter, in the treatment of megaloblastic anemias due to folic acid deficiency, and as an adjunct in the palliative treatment of colorectal carcinoma; administered orally, intramuscularly, or intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

fo·lin·ic ac·id

(fō-lin'ik as'id),
1. The active form of folic acid that acts as a formyl group carrier in transformylation reactions; the calcium salt, leucovorin calcium, has therapeutic use.
2. The term is occasionally applied to other folates.
Farlex Partner Medical Dictionary © Farlex 2012

leucovorin

(lo͞o′kə-vôr′ĭn, lo͞o-kŏv′ər-ĭn)
n.
A form of folic acid that is used to counteract the toxic effects of folic acid antagonists such as methotrexate and is also given as an adjuvant to increase the effectiveness of certain chemotherapy drugs, such as fluorouracil. It is usually given in the form of its calcium salt.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
For detection of caspase-3 activity, we compared two dosages of each extract and we used 10 [micro]g/ml and 8 [micro]g/ml of dosage for ESFAM, leucovorin, and placebo.
Simultaneously, the frequency and dose of leucovorin rescue were increased with continuous hydration and alkalinization to maintain urine pH at 7–9 to eliminate MTX as quickly as possible.
Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: A North Central cancer treatment group phase II study.
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.
Randomized, phase 111 trial of panitumumab with infusional fluorouracil, leucovorin. and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as firstline treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study.
5-FU 370-425 mg/[m.sup.2]/d iv bolus d1-5, Leucovorin 20-25 mg/[m.sup.2]/d iv bolus d1-5, Q4w x 6 cycles.
(4,34,35) All pyrimethamine-containing regimens should also include leucovorin (folinic acid) to prevent drug-induced hematologic toxicity.
Leucovorin is a drug within the "class of medications called folic acid analogs." (103) Leucovorin is most commonly used by cancer patients who receive methotrexate (104) as part of their chemotherapy medication and as a result have very low levels of folic acid, a necessary vitamin for the survival of cells.
Leucovorin belongs to folic acid antagonist antidote class (Fig.
temporarily, which was the case in 2010 for propofol and in 2011 for fos-carnet, norepinephrine, leucovorin, and capecitabine.
The researchers believe that this may be because of the asparaginase in the Capizzi regimen and because another chemotherapy drug, leucovorin, is used as a rescue therapy to help prevent common side effects associated with high doses of methotrexate (e.g., low blood cell counts, mouth sores, diarrhea).