(redirected from leucotriene)

leu·ko·tri·enes (LT),

Products of eicosanoid metabolism (usually, arachidonate) with several physiologic roles, such as mediation of inflammation and participation in allergic reactions; leukotrienes differ from the related prostaglandins and thromboxanes in that they do not have a central ring; so named because they were discovered in association with leukocytes and were initially determined to possess three conjugated double bonds; letters A-F identify the first six metabolites isolated, with subscript numbers to indicate the number of double bonds (for example, leukotriene C4).


a class of biologically active compounds that occur naturally in leukocytes and produce allergic and inflammatory reactions similar to those of histamine. They are thought to play a role in the development of allergic and autoallergic diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis.


(LT) (lū'kō-trī'ēnz)
Products of eicosanoid metabolism with physiologic roles in inflammation and allergic reactions.
Synonym(s): leucotriene.


Powerful chemical agents released by MAST CELLS, basophil cells and MACROPHAGES and involved in many allergic and other immunological reactions. Leukotrienes are derived from ARACHIDONIC ACID and cause CHEMOTAXIS and increase the leakiness of small blood vessels. In asthma they cause the narrowing of the air passages and the secretion of mucus. They can be inhibited by corticosteroid drugs.


A class of small molecules produced by cells in response to allergen exposure; they contribute to allergy and asthma symptoms.
Cells of the blood.


endogenous chemicals (lipids), derived from arachidonic acid, active in the inflammatory process and some allergic responses, and one of the triggers of asthma. Leukotriene receptor-blocking drugs have been developed as part of the treatment regime for asthma and are particularly useful where exercise-induced symptoms are prominent or when there is associated rhinitis.

leukotrienes (lōō·kō·trī·ēnz),

n.pl regulators of inflammatory and allergic reactions. Biologically active leukotrienes are made up of 20-carbon carboxylic acids derived from arachidonic acid.
References in periodicals archive ?
He further suggested that the model used by Couteau et al, (10) that Sayre relies upon, is immune modulated inflammation--not a UV prostaglandin and leucotriene modulated inflammation, which is very difficult to suppress.
Ketoconazole also has anti-inflammatory properties through an action on leucotriene synthesis and it has an action onkeratinisation process through an action on all trans retinoic acid (Levine, 1982).
This indication, that functional selenium and vitamin E status may influence leucotriene metabolism, has important implications in relation to chronic inflammatory disease, particularly asthma which is now the most prevalent chronic inflammatory condition in childhood, and has doubled over the last 20 years in the UK.
Calcium is vital for a large number of functions, including prostaglandin and leucotriene synthesis and a signaling molecule in metabolism.
Prostaglandin inhibition will decrease the cascading inflammatory response, but will also lead to increased leucotriene production through the "overflow" pathway for arachadonic acid.
If there is associated asthma or poor response, the leucotriene receptor antagonists can be tried.
Other modalities used (but not studied) include non-steroidal anti-inflammatory drugs (NSAIDs), thalidomide and leucotriene receptor antagonists.
Natural leucotriene inhibitor from Boswellia: a potential new alternative for treating bronchial asthma.
Ketoconazole also has anti-inflammatory properties through an action on leucotriene synthesis and it has an action on the keratinization process through an action on alltrans retinoic acid (Levine, 1982).
Its component caffeic malic acid was shown to be a leucotriene [B.
Phytosterols are well-known for their soothing, anti-inflammatory effect, due to their cell membrane stabilizing and leucotriene inhibiting properties (supported by literature data).