leukotrienes(redirected from leucotriene)
Products of eicosanoid metabolism (usually, arachidonate) with several physiologic roles, such as mediation of inflammation and participation in allergic reactions; leukotrienes differ from the related prostaglandins and thromboxanes in that they do not have a central ring; so named because they were discovered in association with leukocytes and were initially determined to possess three conjugated double bonds; letters A-F identify the first six metabolites isolated, with subscript numbers to indicate the number of double bonds (for example, leukotriene C4).
a class of biologically active compounds that occur naturally in leukocytes and produce allergic and inflammatory reactions similar to those of histamine. They are thought to play a role in the development of allergic and autoallergic diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis.
Products of eicosanoid metabolism with physiologic roles in inflammation and allergic reactions.
leukotrienesPowerful chemical agents released by MAST CELLS, basophil cells and MACROPHAGES and involved in many allergic and other immunological reactions. Leukotrienes are derived from ARACHIDONIC ACID and cause CHEMOTAXIS and increase the leakiness of small blood vessels. In asthma they cause the narrowing of the air passages and the secretion of mucus. They can be inhibited by corticosteroid drugs.
A class of small molecules produced by cells in response to allergen exposure; they contribute to allergy and asthma symptoms.
Mentioned in: Leukotriene Inhibitors
leukotrienesendogenous chemicals (lipids), derived from arachidonic acid, active in the inflammatory process and some allergic responses, and one of the triggers of asthma. Leukotriene receptor-blocking drugs have been developed as part of the treatment regime for asthma and are particularly useful where exercise-induced symptoms are prominent or when there is associated rhinitis.
n.pl regulators of inflammatory and allergic reactions. Biologically active leukotrienes are made up of 20-carbon carboxylic acids derived from arachidonic acid.