Patients on anticonvulsants like carbamazepin, phenytoin and barbiturates in E.Swart and J Lochner (4) study had acne, leuconychia, linear scars, papular urticaria, verruca vulgaris, tinea pedis and hirsutism.
Laidlaw J (5) states that massive activation of both sympathetic and parasympathetic systems occurs during generalized tonic seizures leading to vasoconstriction of arterioles of nailmatrix ,which leads to parakeratosis and leuconychia. Of 15 cases of Hemiplegia patients 7 had skin lesions (Table.
Dermatosis due to anticonvulsant therapy was seen in 5 cases (10.02%) in the form of a acne vulgaris, leuconychia, gum hypertrophy and linear scar, offending drug found was carbamazepine and phenytoin.
Nail changes such as brittleness, subungual hyperkeratosis, onycholysis and leuconychia
have been reported during pregnancy.4,8,13 In our study most common nail changes are transverse grooves and brittleness of nails which are observed in 2% of females.