leukocidin

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leukocidin

 [loo″ko-si´din]
1. a substance toxic to leukocytes, killing the cells with or without lysis.
2. a type of exotoxin produced by pathogenic bacteria such as staphylococci or streptococci; it destroys leukocytes and may also damage monocytes and macrophages.

leu·ko·ci·din

(lū'kō-sī'din, lū-kō-sī'din),
A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci and manifests a destructive action on leukocytes, with or without lysis of the cells.
[leukocyte + L. caedo, to kill]

leukocidin

/leu·ko·ci·din/ (-si´din) a substance produced by some pathogenic bacteria that is toxic to polymorphonuclear leukocytes (neutrophils).

leukocidin

(1) An antibody which lyses white cells following complement fixation.
(2) A pore-forming cytotoxin produced by certain bacteria.

leu·ko·ci·din

(lū'kō-sī'din)
A heat-labile substance that is elaborated by many strains of Staphylococcus aureus, Streptococcus pyogenes, and pneumococci; manifests a destructive action on leukocytes, with or without lysis of the cells.
Synonym(s): leucocidin.
[leukocyte + L. caedo, to kill]

leukocidin

a substance produced by some pathogenic bacteria that is toxic to polymorphonuclear leukocytes (neutrophils).
References in periodicals archive ?
This multiplex PCR included 16s rRNA gene as internal control and genes for Panton Valentine leucocidin (PVL), toxic shock syndrome toxin, and alpha and beta hemolysins.
Phage conversion of Panton-Valentine leucocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, FSLT.
Wannet WJ, Spalburg E, Heck ME, et al (2005), Emergence of virulent methicillinresistant Staphylococcus aureus strains carrying Panton-Valentine leucocidin genes in The Netherlands.
Osteoarticular infections with Staphylococcus aureus secreting Panton-Valentine leucocidin.
aureus strains produce Panton-Valentine Leucocidin (PVL) a powerful cytotoxin in human and rabbit mononuclear cells.
One marker for CA-MRSA, Panton-Valentine leucocidin (PVL), is most often detected in cases of severe and systemic infection, and it may be a virulence factor.
The presence of mecA and the genes (lukS-PV, lukF-PV) encoding Panton-Valentine leucocidin (PVL) were confirmed by PCR.
1,2) It is often associated with the production of Panton-Valentine leucocidin (PVL), which is responsible for extensive tissue necrosis and a high mortality rate.
A total of 57 of the 86 MRSA isolates (66%; 95% CI 58%-74%) were positive for Panton-Valentine leucocidin t008, consistent with the ST8 USA300 clone.
Polyclonal emergence and importation of community-acquired methicillin-resistant Staphylococcus aureus strains harbouring Panton-Valentine leucocidin genes in Belgium.
The latest recognized strain type of ORSA is community-acquired ORSA (CA-ORSA), that is exceptionally virulent when have the Panton-Valentine leucocidin and is sensitive to antibiotics such clindamycin, cotrimoxazole and doxycycline, which are not tradicionally active against HA-ORSA [25].
A Panton-Valentine leucocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan.