lethal factor


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Encyclopedia.
Related to lethal factor: Bacillus anthracis toxin

ge·net·ic le·thal

a disorder that prevents effective reproduction by those affected; for example, Klinefelter syndrome.

ge·net·ic le·thal

(jĕ-net'ik lē'thăl)
A disorder that prevents effective reproduction by those affected.

lethal factor

1. A gene or an abnormality in genetic composition that causes death of a zygote or of an individual before reproductive age.
2. A protein made by Bacillus anthracis. It splits signal transduction proteins within infected cells, resulting in cellular dysfunction and death.
See also: factor
References in periodicals archive ?
Microbiology data and the time to confirmatory anthrax diagnosis for recipients and nonrecipients of AIG-IV, Scotland, UK, 2009-2010 * Laboratory test AIG-IV nonrecipient Blood culture 32 (8/25)# Wound culture 46.2 (6/13) Tissue culture 54.6 (6/11) Blood PCR 29.4 (5/17)# Blood protective antigen antibody 81.3 (13/16) Blood lethal factor antibody 62.5 (10/16) Days to diagnosis, median (IQR) 3.5 (2.0-30.5), n = 28# Laboratory test AIG-IV recipient p value Blood culture 71.4 (10/14)# 0.02# Wound culture 33.3 (3/9) 0.67 Tissue culture 70 (7/10) 0.66 Blood PCR 80 (8/10)# 0.02# Blood protective antigen antibody 66.7 (4/6) 0.59 Blood lethal factor antibody 57.1 (4/7) 1.00 Days to diagnosis, median (IQR) 2.0 (1.0-3.0), n = 13# 0.006# Values are % patients (no.
Cao, "Neutralizing monoclonal antibody against anthrax lethal factor inhibits intoxication in a mouse model," Human Antibodies, vol.
After screening 10,000 chemicals in 3 days, the researchers found one compound, called DS-998, that blocked the activity of anthrax lethal factor. In a subsequent test, the compound protected lab-grown human cells that later were exposed to the toxin.
Monitoring of ELISA-reactive antibodies against anthrax protective antigen (PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine.
It releases the three components of its toxin--known as lethal factor, edema factor, and protective antigen (PA)--which assemble on cell surfaces.
This diagnosis was supported by seroconversion to protective antigen of Bacillus anthracis and the presence of antibodies against lethal factor. The bacterium itself could not be cultured or identified by polymerase chain reaction (PCR).
Once assembled, the toxin enables lethal factor to enter the cell.