Utility of quantitative polymerase chain reaction in leptospirosis diagnosis: association of level of leptospiremia
and clinical manifestations in Sri Lanka.
2010) and Adler and Moctezuma (2010) because of hepatocellular damage, caused by the leptospiral toxins during leptospiremia
(Birnbaum et al.
Our objectives were to determine if qPCR-determined leptospiremia was associated with severe evolution of the disease and to identify clinical and biological variables associated with severity.
Except for acute renal failure, all complications were associated with a higher level of leptospiremia (online Technical Appendix Table 1, http://wwwnc.
Our results show a strong association between leptospiremia levels and disease severity.
Intervet/Schering-Plough Animal Health indicated that Nobivac Lepto4 was also shown to prevent clinical disease including thrombocytopenia, preserve kidney and liver function and reduce leptospiremia
This is followed by leptospiremia
two to thirty days later, causing the organism to spread to all parts of the body including the meninges.
Sin embargo, la leptospira solo puede ser aislada en sangre u orina durante las fases de leptospiremia
y leptospiruria, respectivamente, lo cual ocurre intermitentemente .
Penicillin is given IV initially to eliminate the leptospiremia
, followed by 3 weeks of oral doxycycline to eliminate the leptospiruria.
La leptospirosis en animales no gestantes son usualmente de tipo subclinico, pero desarrollan anticuerpos poco despues de la leptospiremia
A few studies have demonstrated increased hospitalization rates, disease severity, and leptospiremia
among male patients, which may indicate greater susceptibility for severe disease in male patients (25,29).
Although this molecular technique is highly sensitive and specific for the presence of leptospiremia
(7), more cases may have been detected through the use of microscopic agglutination testing on paired serum samples.