Carcinomatous meningitis: Leptomeningeal metastases
in solid tumors.
In this report, we describe two types of metastases to the CNS, cerebral and leptomeningeal metastases
, from epithelial ovarian carcinoma.
Also, Tagrisso is being investigated in the adjuvant and metastatic first-line settings, including in patients with and without CNS metastases, in leptomeningeal metastases
PATIENTS WITH leptomeningeal metastases
from melanoma have a poor prognosis, but treatment with targeted therapy and immune checkpoint inhibitors increased overall survival and resulted in long-term remission in a few patients, according to researchers.
The relevante of intraventricular chemotherapy for Leptomeningeal metastases
in breast cancer.
Metastasis to the spinal nervous system can be classified as intramedullary, epidural, and leptomeningeal metastases
. Most of the epidural metastases in the spine are associated with vertebral metastases .
Diagnosis and treatment of leptomeningeal metastases
from solid tumours: Experience with 90 patients.
The patient's clinical cytologic exam revealed malignant cells in the CSF, confirming the presence of leptomeningeal metastases
and concordant with our results.
CSF increased levels of vascular endothelial growth factors have been proposed as a promising biomarker with a reported sensitivity of 51-100% and a specificity of 73-100% for leptomeningeal metastases
Glantz, "A comparison between ventricular and lumbar cerebrospinal fluid cytology in adult patients with leptomeningeal metastases
," Neuro-Oncology, vol.
Evolution of computed tomographic anormalities in leptomeningeal metastases
. Ann Neurol 1985; 17:85-9.