Over several decades, emphasis has been placed on understanding, preventing, and treating leprous neuropathy as the source of these disabilities and deformities, and therefore as the root of the stigma associated with Hansen's disease.
Despite the lack of rigorous study, surgical nerve decompression (ND), or neurolysis, has been employed for decades to treat leprous neuropathy.
7-9) In the present study, we apply the surgical approach resulting from the 'double crush hypothesis' to patients with leprous neuropathy when there are indications of nerve compression of one nerve at multiple levels.
The sequential improvement entrapment neuropathy in leprous neuropathy with antileprosy treatment.
The diagnosis of leprous neuropathy was based on clinical examination of cutaneous and neurological system confirmed by histological abnormalities in skin biopsy, skin smear, nerve biopsy.
A wide range of differentials has to be considered as there are no absolutely diagnostic clinical features of leprous neuropathy
9-14) We and others have noted that it is imperative that effective interventions be identified for preventing and treating leprous neuropathy.
Notably, two prospective cohort studies demonstrated that at least 30% of patients with leprous neuropathy did not improve.
In a series of 19 patients having proprioceptive loss in leprous neuropathy
described by Khadilkar et al.
Sural nerve without nerve fibers in leprous neuropathy
To conclude, the results obtained in mouse model for leprous neuropathy indicate the biochemical alterations in the NF, viz.
Degeneration and regeneration of unmyelinated fibers in experimental leprous neuropathy.