leontiasis ossea
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Related to leontiasis ossea: porphyria, platybasia
meg·a·ceph·a·ly
(meg'ă-sef'ă-lē),A condition, either congenital or acquired, in which the head is abnormally large; usually applied to an adult cranium with a capacity of over 1450 mL.
Synonym(s): leontiasis ossea, macrocephaly, macrocephalia, megacephalia, megalocephaly, megalocephalia, Virchow disease
[mega- + G. kephalē, head]
McCune-Albright syndrome
An autosomal dominant condition (OMIM:174800) due to altered regulation of cAMP, endocrinopathy (e.g., hyperthyroidism) and hypophosphatemia.Clinical findings
Precocious puberty, polyostotic (cystic fibrous dysplasia) spontaneous fractures at young age, café-au-lait spots on skin, ovarian cysts.
Lab
Cyclical 4–6-week fluctuations of plasma oestrogen; afflicted young girls have decreased gonadotropins, decreased response to LH-RH; increased testosterone, increased alkaline phosphatase.
Molecular pathology
Defects in GNAS, which encodes a G protein that modulates various membrane signalling cascasdes, cause McCune-Albright syndrome.
Management
Aromatase inhibitor testolactone.
leontiasis ossea
Enlargement and distortion of facial bones, giving one the appearance of a lion. It can occur as a complication of hyperparathyroidism, Paget's disease, uremia, and other conditions.
See also: leontiasis
leontiasis ossea
(lē´əntī´əsis os´ēə),
n an enlargement of the bones of the face, leading to a lionlike appearance. Osseous encroachment may cause obliteration of sinuses, blindness, and malocclusion.
n an enlargement of the bones of the face, leading to a lionlike appearance. Osseous encroachment may cause obliteration of sinuses, blindness, and malocclusion.