lentigo maligna melanoma

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to lentigo maligna melanoma: Acral lentiginous melanoma, Superficial spreading melanoma


a tumor arising from the melanocytic system of the skin and other organs. When used alone, the term refers to malignant melanoma.
acral-lentiginous melanoma an uncommon type of melanoma, although it is the most common type seen in nonwhite individuals, occurring chiefly on the palms and soles, and sometimes involving mucosal surfaces, such as the vulva or vagina. The characteristic lesion is an irregular, enlarging black macule, which has a prolonged noninvasive stage.
lenti´go malig´na melanoma a cutaneous malignant melanoma found most often on the sun-exposed areas of the skin, especially the face. It begins as a circumscribed macular patch of mottled pigmentation, showing shades of dark brown, tan, or black (lentigo maligna or melanotic freckle of Hutchinson), and enlarges by lateral growth before dermal invasion occurs. This type seems to be the least aggressive form of malignant melanoma.
malignant melanoma a malignant skin tumor, usually developing from a nevus and consisting of dark masses of cells with a marked tendency to metastasis. It is not common, but its incidence is increasing and it is the most aggressive type of skin cancer. It arises from pigment- (melanin-) producing cells and varies in course and prognosis according to type; types include superficial spreading melanoma, nodular malignant melanoma, and lentigo maligna melanoma. In general, the superficial lesions can be cured by surgical excision of the mole and adjacent tissues. Deeper lesions tend to metastasize rapidly through the lymphatic and circulatory systems. In some cases the condition has a genetic component. Early detection and skin protection are key in its control.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
Increasing incidence of lentigo maligna melanoma subtypes: northern California and national trends 1990-2000.
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. Dermatol Surg 1998; 24:673-77.
However, the prognosis of lentigo maligna melanoma overall appears to be equal, or slightly better, than that of other melanoma subtypes.
Grande reported the clinic's 4-year history of using the modified Mohs technique to treat lentigo maligna or lentigo maligna melanoma. None of the patients died of the disease.
Figure 3, A through D, illustrates a representative case showing strong nuclear staining with R21 of both in situ and invasive lentigo maligna melanoma. Focal areas with negative R21 staining were observed in 2 of 35 R21-positive cases.
The most common of these subtypes include superficial spreading, nodular, lentigo maligna melanoma, and acral lentiginous.
There was the 93-year-old patient whose "sun spot" had been evaluated and treated by 2 different dermatologists in the past and turned out to be a lentigo maligna melanoma (FIGURE 1).
Four primary groups have been traditionally proposed based on a combination of clinical and pathologic features: superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and acral lentiginous melanoma.