lentigo maligna


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Related to lentigo maligna: Superficial spreading melanoma, Lentigo maligna melanoma

lentigo

 [len-ti´go] (L.)
a flat, brownish pigmented spot on the skin due to increased deposition of melanin and an increased number of melanocytes; a freckle. (See Atlas 2, Part O.)
lentigo malig´na (malignant lentigo) see lentigo maligna melanoma.
senile lentigo (lentigo seni´lis,) (solar lentigo) a small smooth round brownish patch appearing on the face, neck, or back of the hands of many older people, caused by an increase in pigment; these are entirely harmless. Although these spots are associated with aging, it is not age that is the principal cause but many years of exposure to sun and wind. Called also liver spot.

len·ti·go ma·lig·na

a brown or black mottled, irregularly outlined, slowly enlarging lesion resembling a lentigo in which there are increased numbers of scattered atypical melanocytes in the epidermis, usually occurring on the face of older persons; after many years the dermis may be invaded and the lesion is then termed lentigo maligna melanoma.

lentigo maligna

lentigo maligna

Hutchinson's melanotic freckle, lentigo maligna melanoma
A lesion comprising 10% of melanomas, affects those > age 60; flat, indolent, arises in premalignant freckle, located on sun-exposed aging skin; begins as an unevenly pigmented macule with an irregular border, slowly extends peripherally Etiology Solar overexposure,13 progress to melanoma in 10-15 yrs Prognosis > 95% 5-yr survival. See Lentigo, Melanoma.

len·ti·go ma·lig·na

(len-tī'gō mă-lig'nă)
A brown or black mottled, irregularly outlined, slowly enlarging lesion resembling a lentigo in which there are increased numbers of scattered atypical melanocytes in the epidermis, usually occurring on the face of older persons; after many years the dermis may be invaded and the lesion is then termed lentigo maligna melanoma.
Synonym(s): Hutchinson freckle.
Enlarge picture
LENTIGO MALIGNA: SOURCE: Centers for Disease Control and Prevention; Carl Washington, MD

lentigo maligna

A pigmented lesion of the skin in which a large number of superficial, atypical melanocytes are found. Synonym: Hutchinson's freckle
See: illustration
See also: lentigo

Hutchinson,

Sir Jonathan, English surgeon and pathologist, 1828-1913.
Hutchinson crescentic notch - the semilunar notch on the incisal edge of Hutchinson teeth, encountered in congenital syphilis.
Hutchinson disease - age-related guttate choroiditis.
Hutchinson facies - the peculiar facial expression produced by drooping eyelids and motionless eyes in external ophthalmoplegia.
Hutchinson freckle - a brown or black mottled, irregularly outlined, slowly enlarging lesion. Synonym(s): lentigo maligna
Hutchinson mask - the sensation experienced in tabetic neurosyphilis as if the face were covered with a mask or with cobwebs.
Hutchinson patch - interstitial or parenchymatous keratitis giving rise to neovascularization of the cornea. Synonym(s): salmon patch
Hutchinson pupil - dilation of the pupil on the side of the lesion as part of a third nerve palsy.
Hutchinson teeth - the teeth of congenital syphilis in which the incisal edge is notched and narrower than the cervical area. Synonym(s): notched teeth; screwdriver teeth; syphilitic teeth
Hutchinson triad - parenchymatous keratitis, labyrinthine disease, and Hutchinson teeth, significant of congenital syphilis.
Hutchinson-Gilford disease - a condition in which normal development in the first year is followed by gross retardation of growth, with dry wrinkled skin, total alopecia, and birdlike facies. Synonym(s): Hutchinson-Gilford syndrome; progeria
Hutchinson-Gilford syndrome - Synonym(s): Hutchinson-Gilford disease
References in periodicals archive ?
McKenna JK, Florell SR, Goldman GD, Bowen GM: Lentigo maligna/ lentigo maligna melanoma: current state of diagnosis and treatment.
Cohen LM: Lentigo maligna and lentigo maligna melanoma.
independently examined 41 cases of classic lentigo maligna and 38 cases of reactive lentiginous melanocytic hyperplasia incidentally found on excision and/or biopsy specimens of nonmelanoma skin cancer during the period of July 1 to October 15, 2011 (see below).
The modified protocol takes advantage of the high level of sAC expression in lentigo maligna and achieves conditions that preserve the pan-nuclear staining in lentigo maligna but minimize staining in benign melanocytes and other cell types.
Another fortunately rare clinical variant of lentigo maligna presents as an enlarging, hypopigmented or erythematous, scaly patch resembling eczema, Bowen disease (squamous cell carcinoma in situ), or a superficial basal cell carcinoma.
Whether clinically hyperpigmented or amelanotic, some authors (26) consider lentigo maligna to be an earlier atypical melanocytic proliferation (hyperplasia) on chronically sun-damaged skin histologically distinct from melanoma in situ, lentigo maligna type, the preinvasive form of lentigo maligna melanoma.
In sharp contrast to lentigo maligna, there is only limited or no solar elastosis.
The unique clinical and histologic features discussed above and summarized in Table 2 suggest that lentiginous melanoma represents a distinct clinicopathologic entity from a common lentiginous nevus, dysplastic nevus, superficial spreading melanoma, and lentigo maligna.
This finding supports our theory that drivers who regularly spend more time in the car over the course of several years are more likely to develop skin cancers on the left side of the body, particularly skin cancers like basal cell carcinoma and lentigo maligna that develop gradually over time.
Grande reported the clinic's 4-year history of using the modified Mohs technique to treat lentigo maligna or lentigo maligna melanoma.
2,5,9) Conversely, lentigo maligna melanoma is limited to the skin areas most exposed to sunlight and is characterized by longer intraepidermal or radial growth phases (long RGP) (Figure 1).
During the observation period, 23 patients (29%) had lesions that progressed from AK to AK with squamous cell carcinoma, 38 (48%) developed basal cell carcinoma, 6 (7%) were found to have lentigo maligna, and 1 was found to have lentigo maligna melanoma.