lenograstim

CSF3

A gene on chromosome 17q11.2-q12 that encodes colony stimulating factor 3 (granulocyte), a cytokine that controls the production, differentiation and function of granulocytes, the active protein product of which is located extracellularly.

lenograstim

Human GRANULOCYTE-STIMULATING FACTOR produced by genetic engineering and used to treat severe deficiencies of some of the white cells of the blood and the immune system. A brand name is Granocyte.
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Filgrastim XM02 (Tevagrastim[R]) after autologous stem cell transplantation compared to lenograstim: favourable cost-efficacy analysis.
Granocyte (lenograstim) recombined human granulocyte colony-stimulating factor involved in the production of granulocytes, macrophages, and megakaryocytes.
Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study.
Comparison of outcome of allogeneic bone marrow transplantation with and without granulocyte colony-stimulating factor (lenograstim) donor-marrow priming in patients with chronic myelogenous leukemia.
Patients receiving gemcitabine plus docetaxel were assumed to receive treatment with lenograstim to prevent neutropenic complications; those with prior pelvic irradiation were assumed to receive a 25% dose reduction of gemcitabine plus docetaxel [33].
Synthetic G-CSF (granulocyte colony stimulating factor, e.g., filgrastim, lenograstim) is also being prescribed to improve the corresponding neutropenia (a decrease of the neutrophil granulocyte count below 0.5x[10.sup.9]/L) in recent years (2).
Existing G-CSF products are marketed as Filgrastim (E.coli derived) and Lenograstim (CHO derived).
On day 14 after admission, at the onset of pancytopenia, subcutaneous administration of recombinant human G-CSF (Lenograstim; Chugai Pharmaceutical Co.