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Under the mistaken assumption that these tumors originated from smooth muscle cells, they designated them as leiomyoblastoma, leiomyoma, and leiomyosarcoma, based on their morphologic appearance.
Key Words: gastrointestinal stromal tumor, leiomyoblastoma, lymph node metastasis
Gastrointestinal stromal tumors were originally described as leiomyomas or leiomyoblastomas involving the smooth muscle of the gastrointestinal tract.
This finding should not be surprising, given the many cytologic variants that are known to occur among uterine leiomyomas, such as epithelioid leiomyoma, stromomyoma, leiomyoblastoma, clear cell leiomyoma, bizarre leiomyoma, and plexiform leiomyoma.
3-5] The spindle cell neoplasms of the gastrointestinal tract were called leiomyoma or leiomyosarcoma, and the predominant round or polygonal cell variant was named epithelioid leiomyoma, leiomyoblastoma, or epithelioid leiomyosarcoma.
Omental bleeding has also been associated with varices (3), hemangiopericytomas, leiomyoblastomas, omental torsion (2), aneurysms (4), and an aneurysm in a peritoneal dialysis patient (5), none of which were identified in the described patient.
This advance meant that tumors previously classified as leiomyomas, leiomyosarcomas, and leiomyoblastomas could be correctly recognized as GISTs.
Leiomyoblastomas and their relationship to other smooth-muscle tumors of the gastrointestinal tract: an electron-microscopic study.
Cytokeratins occasionally stain positive in epithelioid variants, known as leiomyoblastomas.