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Conventional DMARD usage reflected the contemporary treatment paradigm with methotrexate, hydroxychloroquine, leflunomide, and sulfasalazine being the predominant cDMARDs used.
Additionally, this is the first report suggesting a better effect of methotrexate compared to two other csDMARDs (leflunomide and hydroxychloroquine) in prevention of ATI development.
Leflunomide is an immunosuppressant used primarily in the treatment of rheumatoid and psoriatic arthritis.
In Leflunomide group, 100 (68.02%) patients had moderate response and 47 patients had no response.
The generic Arava ( Leflunomide tablet) is authorised for people living with rheumatoid arthritis (RA) and works by blocking the autoimmune antibodies that reduce inflammation with the aim of improving mobility.
The multiple regression model showed that the HBV reactivation risk of RA patients treated by leflunomide was increased by 30% by the basic state of hepatitis B as well as alanine transaminase level and swollen joint count before treatment.
Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation, 81(5), 704-710.
Conventional synthetic DMARDs therapy (MTX and leflunomide) was continued until March 2011, when the treatment was stopped because of hepatocytolysis.
17 patients of leflunomide group were treated with oral leflunomide l00 mg for first three days followed by 20 mg daily.
Prednisone was reduced to 5 mg, and leflunomide was washed out with cholestyramine.
Sulfasalazine and Leflunomide May be Considered Sulfasalazine received FDA approval in 1998 after a trial demonstrated efficacy in JIA versus placebo.