CLEC7A

(redirected from lectin-like receptor 1)

CLEC7A

A gene on chromosome 12p13.2 that encodes a C-type lectin domain protein which acts as a pattern receptor for beta-1,3-linked and beta-1,6-linked glucans found in pathogenic bacteria and fungi. CLEC7A is required for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappB. It enhances cytokine production in macrophages and dendritic cells, plays a role in T-cell activation and proliferation, and mediates production of reactive oxygen species and phagocytosis of Candida albicans.
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Numerous other groups identified this receptor and named it C-type lectin-like molecule-1 (CLL-1), DC associatedC-type lectin 2 (DCAL-2), and killer cell lectin-like receptor 1 (KLRL1) [153-155].