Lecithin-cholesterol acyltransferase | definition of lecithin-cholesterol acyltransferase by Medical dictionary
Also found in: Acronyms
lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase (LCAT), (les'i-thin-kō-les'tĕr-ōl as'ĭl-trans'fĕr-ās),
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.
lecithin–cholesterol acyltransferase /lec·i·thin–cho·les·ter·ol ac·yl·trans·fer·ase/ (LCAT) (kah-les´ter-ol a″sil-trans´fer-ās) an enzyme that catalyzes the formation of cholesteryl esters in high-density lipoproteins; deficiency of enzyme activity, an inherited disorder, results in accumulation of cholesterol and phosphatidylcholine in plasma and tissues, which causes corneal opacities, anemia, and often proteinuria.
References in periodicals archive
Bolin DJ, Jonas A Sphingomyelin inhibits the lecithin-cholesterol acyltransferase
reaction with reconstituted high density lipoproteins by decreasing enzyme binding.
LpX is also seen in lecithin-cholesterol acyltransferase deficiency and may contribute to nephropathy related to lecithin-cholesterol acyltransferase deficiency (4).
A novel in vivo lecithin-cholesterol acyltransferase (LCAT)deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.
LPC is a relevant component of human plasma originating from lecithin-cholesterol acyltransferase
, hepatic secretion (4, 5), or action of phospholipase [A.
Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase
deficiency in alcoholic liver disease.