lecithin-cholesterol acyltransferase


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lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase (LCAT),

(les'i-thin-kō-les'tĕr-ōl as'ĭl-trans'fĕr-ās),
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.

lecithin–cholesterol acyltransferase

/lec·i·thin–cho·les·ter·ol ac·yl·trans·fer·ase/ (LCAT) (kah-les´ter-ol a″sil-trans´fer-ās) an enzyme that catalyzes the formation of cholesteryl esters in high-density lipoproteins; deficiency of enzyme activity, an inherited disorder, results in accumulation of cholesterol and phosphatidylcholine in plasma and tissues, which causes corneal opacities, anemia, and often proteinuria.
References in periodicals archive ?
6-8) The LXR-mediated genes include apo A1, lecithin-cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), and SRB1, which are all involved in reverse cholesterol transport.
2] Human genes: PCSK9, proprotein convertase subtilisin/kexin type 9; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; APOA1, apolipoprotein A-I; LCAT, lecithin-cholesterol acyltransferase.
Bolin DJ, Jonas A Sphingomyelin inhibits the lecithin-cholesterol acyltransferase reaction with reconstituted high density lipoproteins by decreasing enzyme binding.
A novel in vivo lecithin-cholesterol acyltransferase (LCAT)deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.
LPC is a relevant component of human plasma originating from lecithin-cholesterol acyltransferase, hepatic secretion (4, 5), or action of phospholipase [A.
Because of the possible generation of LPC species by lecithin-cholesterol acyltransferase or phospholipase [A.
Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.