leader sequence


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leader region

or

leader sequence

a sequence of NUCLEOTIDES at the 5'-END of MESSENGER RNA (and on DNA), UPSTREAM of the start CODON for TRANSLATION. This sequence contains the RIBOSOME BINDING SITE but is not normally translated into a part of the PROTEIN of the GENE. In some cases it contains a regulatory region called an ATTENUATOR.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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Translational regulation of angiotensin type la receptor expression and signaling by upstream AUGs in the 5' leader sequence. J Biol Chem 2004:279(44):45322-45328.
HLA-E is expressed by all nucleated cells and binds peptides derived from the leader sequence of other HLA-class I molecules.
Years later, in 1993, the team of researcher Juan Francisco Martinez Mojica of the University of Alicante, Spain, independently reported the same finding but in archaeal genomes, and described the sequences as repetitive and palindromic, which were separated from each other by means of spacer sequences, and which had a leader sequence at their start (4).
It was recently demonstrated that proteins can be unfolded as they are pulled through the [alpha]HL pore, with either a DNA leader sequence (37) or a motor protein (38).
Growth hormone cDNA of Beetal goat (Capra hircus) an indigenous breed of Punjab Pakistan was amplified by RT PCR and gene including leader sequence was cloned in pTZR57 cloning vector.
In the study in mice, a prototype monoclonal antibody construct encoding for an established anti-HIV monoclonal antibody (VRC01) was created as a DNA plasmid using the firm's DNA optimisation technology, including codon/RNA optimisation and leader sequence utilisation, and delivered with its Cellectra adaptive electroporation device.
Multiple sequence alignment revealed conserved leader sequence of 24 amino acids and a potential N-linked glycosylation site, that is, Asn-Thr-Thr at positions 64-66.
Cleavage at an upstream Q73/A would not generate an N terminal G, cleavage at this site is not supported by NetPicoRNA prediction, and the presence of a leader sequence is unclear (Figure 1; www.cbs.dtu.dk/services/ NetPicoRNA).
Between these two extremes of the arbitrary, resolutely nonnarrative coupling of image and sound, one sees all manner of footage from old propaganda films, especially from Vietnam and China (with the material often showing signs of damage), as well as a projection that with its many back-to-back leader sequence countdowns looks like a self-reflexive loop.
The differences among these vectors are mainly in the leader sequence that precedes the viral genes.