leader sequence


Also found in: Wikipedia.

leader region

or

leader sequence

a sequence of NUCLEOTIDES at the 5'-END of MESSENGER RNA (and on DNA), UPSTREAM of the start CODON for TRANSLATION. This sequence contains the RIBOSOME BINDING SITE but is not normally translated into a part of the PROTEIN of the GENE. In some cases it contains a regulatory region called an ATTENUATOR.

leader sequence

the nontranslated section of mRNA before the coding region.
References in periodicals archive ?
Translational regulation of angiotensin type la receptor expression and signaling by upstream AUGs in the 5' leader sequence.
Years later, in 1993, the team of researcher Juan Francisco Martinez Mojica of the University of Alicante, Spain, independently reported the same finding but in archaeal genomes, and described the sequences as repetitive and palindromic, which were separated from each other by means of spacer sequences, and which had a leader sequence at their start (4).
In the study in mice, a prototype monoclonal antibody construct encoding for an established anti-HIV monoclonal antibody (VRC01) was created as a DNA plasmid using the firm's DNA optimisation technology, including codon/RNA optimisation and leader sequence utilisation, and delivered with its Cellectra adaptive electroporation device.
For murine hepatitis virus and several CoVs, an [approximately equal to]70bp leader sequence is added to the 5?
Between these two extremes of the arbitrary, resolutely nonnarrative coupling of image and sound, one sees all manner of footage from old propaganda films, especially from Vietnam and China (with the material often showing signs of damage), as well as a projection that with its many back-to-back leader sequence countdowns looks like a self-reflexive loop.
Both vectors contain the cytomegalovirus (CMV) immediate early promoter, including the intron A, the bovine growth hormone polyadenylation signal, and the tPA leader sequence.
After introduction of the leader sequence into the mammalian expression vector pcDNA3.
Compositions of the invention are nucleotide sequences encoding a signal peptide sequence for a yeast secreted protein, an optional leader peptide sequence for a yeast secreted protein, a native propeptide leader sequence for a mature protein of interest, and a sequence for the mature protein of interest, all operably linked to a yeast promoter.
They appear to be translated as inactive prepeptides containing an N-terminal leader sequence and a C-terminal propeptide component.
The present study sought to map the sites of inhibition of in vitro translation of the movement protein by hybridizing a series of test ASOs to the 5' leader sequence of BMV RNA 3.
Posiphen represses -Synuclein mRNA translation by its 5' leader sequence by interfering with the selective binding of an essential Iron Regulatory Protein, IRP-1, to the functional RNA enhancer in front of the -Synuclein messenger.
Further optimisation processes were conducted including codon/RNA optimisation, and addition of a Kozak sequence and IgE leader sequence to enhance the expression of the vaccine in humans.