lead optimization

lead optimization

(lēd)
The synthetic refinement of a candidate drug from its crude or original state into an agent that is safer, more useful, or more marketable.
References in periodicals archive ?
Lead optimization for medicinal chemists; pharmacokinetic properties of functional groups and organic compounds.
Elixir is advancing a novel proprietary potent, orally available ghrelin antagonist through lead optimization and is preparing to nominate a clinical candidate.
Anticipated applications for biomarkers include drug discovery and lead optimization, pre-clinical and clinical development, patient diagnostics, toxicity testing, targeted therapeutics, and treatment tracking and prognostics.
Kemia's competitive advantage includes proprietary chemistries for allosteric inhibition of kinases and for modulation of GPCRs (G-protein coupled receptors), a multi-disciplinary approach to medicinal chemistry, and rigorous ADME and pharmacokinetic evaluation integrated into the lead optimization process.
Used worldwide by the life sciences, biotechnology, and pharmaceutical industries, as well as clinical testing institutions (outside the United States and Europe), Guava's products have broad applications in scientific research and throughout the drug discovery and lead optimization process, as well as for cell counting and optimization of commercial bio-pharmaceutical production.
Arrow also has a Hepatitis C polymerase programme in lead optimization.
HTG's qNPA(TM) technology is used to carry out quantitative multiplexed, gene-based drug discovery programs, including target validation, HTS lead optimization, metabolism, toxicology and clinical development.
HTG's ArrayPlate qNPA(TM) technology is used to carry out quantitative multiplexed, gene-based drug discovery programs, including target validation, HTS lead optimization, metabolism, toxicology and clinical development.
Following on our previous successes, we are well positioned to continue progression through lead optimization and to deliver proof-of-concept data for one or more of our novel COMT inhibitors," said Dr.
The program reached clinical trials in less than two years from initiation, spending less than six months in lead optimization, with less than 50 compounds synthesized.
KinomeScan significantly accelerates drug discovery and development, from early discovery screening through lead optimization and into the preclinical and clinical stages," said Shripad Bhagwat, Ph.
Used worldwide by the life science, biotechnology, and pharmaceutical industries, Guava's products have broad applications in scientific research and throughout the drug discovery and lead optimization process, as well as for cell counting, cell health profiling, and the optimization of commercial bio-pharmaceutical production.