lead optimization

lead optimization

(lēd)
The synthetic refinement of a candidate drug from its crude or original state into an agent that is safer, more useful, or more marketable.
References in periodicals archive ?
DNDi and Takeda are working on the lead optimization of the aminopyrazole series.
Lead optimization for medicinal chemists; pharmacokinetic properties of functional groups and organic compounds.
a cheminformatics software and service provider, announced the release of the latest version of ClassPharmer Suite for Screening Data Analysis, Hit-to-Lead Development, Lead Optimization, and Predictive Toxicology.
Anticipated applications for biomarkers include drug discovery and lead optimization, pre-clinical and clinical development, patient diagnostics, toxicity testing, targeted therapeutics, and treatment tracking and prognostics.
Atheris Laboratories, a world leading company in venom-based drug discovery and lead optimization, and Debiopharm Group(TM) (Debiopharm), a Swiss-based global biopharmaceutical company developing prescription drugs that target unmet medical needs including oncology along with companion diagnostics, today announced the signature of a collaboration agreement regarding the Atheris "Reverse-Discovery"(TM) lead optimization platform.
May 24 /PRNewswire/ -- IBC's Lead Discovery and Lead Optimization Conference will address the challenges in the lead identification, hit to lead and lead optimization stages of drug discovery.
Used worldwide by the life sciences, biotechnology, and pharmaceutical industries, as well as clinical testing institutions (outside the United States and Europe), Guava's products have broad applications in scientific research and throughout the drug discovery and lead optimization process, as well as for cell counting and optimization of commercial bio-pharmaceutical production.
HTG's qNPA(TM) technology is used to carry out quantitative multiplexed, gene-based drug discovery programs, including target validation, HTS lead optimization, metabolism, toxicology and clinical development.
5 billion market for lead optimization tools and services in drug discovery is growing at an annual rate in excess of 20%, according to a new study released today from Kalorama Information, and approaches employing in silico models are growing faster than any other method.
HTG's ArrayPlate qNPA(TM) technology is used to carry out quantitative multiplexed, gene-based drug discovery programs, including target validation, HTS lead optimization, metabolism, toxicology and clinical development.
deuxo, a provider of sales lead optimization solutions and services, today announced a $10 million Series B financing.
Kemia's competitive advantage includes proprietary chemistries for allosteric inhibition of kinases and for modulation of GPCRs (G-protein coupled receptors), a multi-disciplinary approach to medicinal chemistry, and rigorous ADME and pharmacokinetic evaluation integrated into the lead optimization process.