lead molecule

lead molecule

(lēd)
A chemical compound thought to be useful, safe, and distinctive enough that it might prove to be a good candidate for drug development.
References in periodicals archive ?
Aduro's lead molecule, ADU-S100 (MIW815), is the first therapeutic in development specifically targeting STING.
Cocrystal's novel, potent, broad spectrum anti-influenza preclinical lead molecule, CC-42344, targets the cap-binding PB2 domain and is active against a panel of seasonal, pandemic, and Tamiflu-resistant influenza A strains.
In partnership with MD Anderson and Baylor College of Medicine, Fannin and Atrapos will use the NIH grant to further develop the company's lead molecule, PM-43I, which has demonstrated encouraging activity in mouse models of allergic asthma including a significant reduction in airway hyper-responsiveness.
Its lead molecule is an antibody to treat prostate cancer.
Cavion's lead molecule, CX-8998, has been evaluated in a Phase 2 randomised, placebo-controlled clinical study in patients with essential tremor.
Its lead molecule, CX-8998, has been evaluated in a Phase 2 randomized, placebo-controlled clinical study in patients with essential tremor.
They tested the lead molecule in HIV infection models and found that it significantly delayed dormant HIV reactivation after ART cessation in blood cells of ART-treated, HIV infected people.
In May 2018, we presented preclinical data on NCX 667, a lead molecule among our future generation stand-alone NO-donors.
The current research is based on the search for some plant biochemicals in the form of the single compound which is like lead molecule concerned with particular target linked with disease.
(5) As carbonyl group makes H-bonding in most of the cases, its presence seems to be essential in case of PCNP lead molecule.
These all molecules are purchasable, so, any lead molecule can be purchased and are delivered within a period of up to 10 weeks depending upon the availability.
Summary: Bioisosterism has unique relevance in the field of pharmaceutical sciences and is conducted to curtail side effects or to alter the biological activity of a lead molecule. In the biomedical field, the aim of exchanging one bioisostere for another is to boost the preferred pharmacological, biological or physical qualities of a substance without making substantial changes in the chemical skeleton.