lazy leukocyte syndrome

lazy leukocyte syndrome

 

a syndrome occurring in children, marked by recurrent low-grade infections, associated with a defect in neutrophil chemotaxis and deficient random mobility of neutrophils.

lazy leukocyte syndrome

an immunodeficiency disease of children characterized by recurrent stomatitis, gingivitis, otitis media, and low-grade fever with severe neutropenia. The condition has been associated with abnormal chemotaxis by leukocytes. It is treated with normal human serum transfusions.

An idiopathic condition due to defective neutrophil chemotaxis after appropriate stimuli—e.g., endotoxin or epinephrine—and inefficient egress of neutrophils from the BM
Prognosis Uncertain

lazy leukocyte syndrome

An idiopathic condition due to defective PMN chemotaxis after appropriate stimuli–eg, endotoxin or epinephrine and inefficient egress of PMNs from the BM Clinical ↑ Pyogenic infections–eg, gingivitis, abscess formation, pneumonia, neutropenia Prognosis Uncertain

lazy leukocyte syndrome

decreased responsiveness of leukocytes in chemotactic assays.